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公开(公告)号：EP1720876A1
公开(公告)日：2006-11-15
申请号：EP05723683.8
申请日：2005-02-25
发明人： WIZEL, Shlomit , ARONHIME, Judith , NIDDAM-HILDESHEIM, Valerie , DOLITZKY, Ben-Zion , ETINGER, Marina, Yu , YUZEFOVICH, Michael , NISNEVICH, Gennady, A. , PERTSIKOV, Boris , TISHIN, Boris , BLASBERGER, Dina
IPC分类号： C07D473/18 , A61K31/522 , A61P31/18
CPC分类号： A61K31/522 , C07D473/00 , C07D473/18
摘要： Provided are novel polymorphs and pseudopolymorphs of valacyclovir hydrochloride and pharmaceutical compositions containing these. Also provided are methods for making the novel polymorphs and pseudopolymorphs, which include valacyclovir hydrochloride monohydrate and valacyclovir hydrochloride dihydrate.
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公开(公告)号：EP1465894A2
公开(公告)日：2004-10-13
申请号：EP02793918.0
申请日：2002-11-13
发明人： ETINGER, Marina, Yu , YUDOVICH, Lev, M. , YUZEFOVICH, Michael , NISNEVICH, Gennady, A. , DOLITZKI, Ben, Zion , PERTSIKOV, Boris , TISHIN, Boris , BLASBERGER, Dina
IPC分类号： C07D473/18
CPC分类号： C07D473/00
摘要： The present invention relates to protected valacyclovir, N-tert-butoxycarbonyl-L-valine 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy] ethyl ester, and a method of making it. The present invention further relates to a method of making valacyclovir including the steps of coupling an amine protected valine selected from N-tbutoxycarbonyl valine and N-formyl valine with acyclovir using a coupling agent to form a protected valacyclovir, and deprotecting the protected valacyclovir to form valacyclovir or a pharmaceutically acceptable salt thereof. The present invention further relates to valacyclovir in pure form, a method of making pure valacyclovir, and to compositions containing pure valacyclovir.
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3.发明公开CRYSTALLINE VENLAFAXINE BASE AND NOVEL POLYMORPHS OF VENLAFAXINE HYDROCHLORIDE, PROCESSES FOR PREPARING THEREOF 审中-公开晶体和盐酸文拉法辛新文拉法辛多晶型，用于生产
公开(公告)号：EP1474379A2
公开(公告)日：2004-11-10
申请号：EP02791279.9
申请日：2002-11-20
IPC分类号： C07C211/00
CPC分类号： C07C217/74 , C07C213/10 , C07C2601/14
摘要： The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: i) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.
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