发明授权
- 专利标题: BESTIMMUNG EINES MIDREGIONALEN PROADRENOMEDULLIN-TEILPEPTIDS IN EINER BIOLOGISCHEN FLÜSSIGKEIT ZU DIAGNOSTISCHEN ZWECKEN SOWIE IMMUNOASSAYS FÜR DIE DURCHFÜHRUNG EINER SOLCHEN BESTIMMUNG
- 专利标题(英): Identifying a midregional proadrenomedullin partial peptide in biological liquids for diagnostic purposes, and immunoassays for conducting an identification of this type
- 专利标题(中): 一中段肾上腺髓质素部分肽的变化用于诊断目的和该决定的实施生物液体免疫分析测定
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申请号: EP04700013.8申请日: 2004-01-29
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公开(公告)号: EP1488209B1公开(公告)日: 2005-12-07
- 发明人: BERGMANN, Andreas , STRUCK, Joachim
- 申请人: B.R.A.H.M.S Aktiengesellschaft
- 申请人地址: Neuendorfstrasse 25 16761 Hennigsdorf DE
- 专利权人: B.R.A.H.M.S Aktiengesellschaft
- 当前专利权人: B.R.A.H.M.S Aktiengesellschaft
- 当前专利权人地址: Neuendorfstrasse 25 16761 Hennigsdorf DE
- 代理机构: Andrae, Steffen
- 优先权: DE10316583 20030410
- 国际公布: WO2004090546 20041021
- 主分类号: G01N1/00
- IPC分类号: G01N1/00 ; G01N33/74 ; G01N33/68
摘要:
The invention relates to a method for identifying adrenomedullin immunoreactivity in biological liquids for diagnostic purposes and, to be precise, particularly within the scope of sepsis diagnosis, cardiac diagnosis and cancer diagnosis. According to the invention, the midregional partial peptide (mid-proAM; SEQ ID NO:3) of the proadrenomedullin, which contains amino acids (45-92) of the entire preproadrenomedullin (pre-proAM; SEQ ID NO:1), is measured, in particular, with an immunoassay which works with at least one labeled antibody that specifically recognizes a sequence of the mid-proAM.
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