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1.发明授权VERFAHREN UND SUBSTANZEN FÜR DIE DIAGNOSE UND THERAPIE VON SEPSIS UND SEPSISÄHNLICHEN SYSTEMISCHEN INFEKTIONEN 有权方法和物质进行诊断和治疗脓毒症和败血症样全身性感染
公开(公告)号：EP1121600B2
公开(公告)日：2014-06-25
申请号：EP99953805.1
申请日：1999-10-13
IPC分类号： G01N33/74 , C07K14/585 , A61K38/23 , A61K38/22
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
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2.发明公开METHOD FOR THE SELECTIVE DETERMINATION OF PROCALCITONIN 1-116 FOR DIAGNOSTIC PURPOSES AND ANTIBODIES AND KITS FOR CARRYING OUT SUCH A METHOD 有权处理该选择性测定降钙素原1-116用于诊断目的和抗体以及试剂盒实施该方法
公开(公告)号：EP2032992A1
公开(公告)日：2009-03-11
申请号：EP08715933.1
申请日：2008-02-21
发明人： BERGMANN, Andreas , STRUCK, Joachim
IPC分类号： G01N33/74 , C07K16/26 , C07K14/585
CPC分类号： G01N33/6854 , C07K16/26 , C07K2317/34 , G01N33/74 , G01N2333/585
摘要： Immunoassay for procalcitonin in a biological sample from a patient comprises selectively determining full-length procalcitonin 1-116 with alanine and proline at positions 1 and 2. An independent claim is also included for an antibody that selectively binds to procalcitonin 1-116.
摘要翻译： 免疫测定法，用于从患者的生物样品中的降钙素原包括选择性确定性采矿全长降钙素原1-116与丙氨酸和脯氨酸在位置1和2，一种独立claimsoft因此包含在抗体做选择性结合降钙素原1-116。
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公开(公告)号：EP2028493A1
公开(公告)日：2009-02-25
申请号：EP08075749.5
申请日：1999-10-13
IPC分类号： G01N33/74 , C07K14/585 , A61K38/23 , A61K38/22
CPC分类号： G01N33/74 , C07K14/585 , G01N2333/585
摘要： Isoliertes Procalcitonin 3-116, Verfahren zur seiner Isolierung aus dem Blut von Sepsispatienten und die Verwendung von Procalcitonin 3-116 als Parameter in der allgemeinen Diagnostik.
摘要翻译： 用于从败血症患者的血液和使用降钙素原3-116的如在一般诊断参数其隔离的分离的降钙素原3-116，过程。
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4.发明授权VERWENDUNGEN DER CARBAMOYLPHOSPHAT SYNTHETASE 1 (CPS 1) UND IHRER FRAGMENTE FÜR DIE DIAGNOSE VON SEPSIS 有权作者：1个氨甲酰磷酸合成使用I（CPS 1）及其碎片作诊断败血症
公开(公告)号：EP1497662B1
公开(公告)日：2006-09-13
申请号：EP03725036.2
申请日：2003-04-15
IPC分类号： G01N33/68 , G01N33/569 , G01N33/573
CPC分类号： G01N33/6893 , C12Q1/34 , C12Q1/48 , G01N2333/9015 , G01N2800/26
摘要： The invention relates to the use of the carbamoyl phosphate synthetase 1 (CPS 1) and/or fragments of the N-terminal part of the CPS 1 of body fluids or body tissues, as marker peptides for diagnostic detection, and for the prognosis and control of the development of inflammations and infections, including sepsis, and liver failure in the case of multi-organ failure, or for determinations relating to inflammatory liver diseases and other liver diseases.
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公开(公告)号：EP1499896B1
公开(公告)日：2006-08-23
申请号：EP03724960.4
申请日：2003-04-04
发明人： BERGMANN, Andreas
IPC分类号： G01N33/574 , G01N33/564
CPC分类号： G01N33/564 , G01N33/57488 , G01N2405/10
摘要： Disclosed is a method for the early detection of neoplasms in a patient and for assessing the danger represented by developing and/or spreading malignant neoplasms. The inventive method is characterized by the fact that the presence and quantity of antibodies (i) which bond to ganglioside structures and antigen structures simulating ganglioside structures, and (ii) the presence of which and/or the quantities of highly sensitive antibodies being significantly greater than in normal individuals correlating with the existence of a neoplasm and/or the patient's health being jeopardized by malignant neoplasms, is determined in a biological sample of the patient by using an assay that is highly sensitive to the antibodies that are to be determined.
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公开(公告)号：EP1562984B1
公开(公告)日：2006-08-09
申请号：EP03785634.1
申请日：2003-10-16
发明人： BERGMANN, Andreas , STRUCK, Joachim
CPC分类号： G01N33/76 , G01N33/6893 , G01N2333/58
摘要： Disclosed is an improved sandwich immunoassay for identifying partial proANP peptides in cardiac and sepsis diagnosis by using two antibodies which specifically bond to partial sequences in the midregional area of NT-proANP, said area extending from amino acid 53 to amino acid 83 of NT-proANP.
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7.发明公开Novel monoclonal thyroid stimulating or blocking antibodies, peptide sequences corresponding to their variable regions, and their uses in diagnostic, preventive and therapeutic medicine 有权单克隆甲状腺刺激或阻断相应Peptidesquenzen其可变区的抗体，以及它们在诊断，预防和治疗药物中的用途
公开(公告)号：EP1612224A1
公开(公告)日：2006-01-04
申请号：EP04015239.9
申请日：2004-06-29
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2869 , A61K2039/505 , C07K2317/34 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/564 , G01N33/76
摘要： Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab') 2 , Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blokking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSH receptors (TSHr) from different animals. Various uses of such anitbodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.
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8.发明公开Diagnose von Sepsis durch selektive Bestimmung der Konzentration der Cu/Zn Superoxiddismutase (Cu/Zn SOD) in Patientenproben 审中-公开诊断病人咳嗽中的脓毒症urch urch ive ive der en en en en en en en en en en en en en en en en en en en en en
公开(公告)号：EP1562046A1
公开(公告)日：2005-08-10
申请号：EP04002355.8
申请日：2004-02-03
IPC分类号： G01N33/68 , G01N33/569 , C12Q1/28
CPC分类号： C12Q1/28 , G01N33/56911 , G01N33/6893 , G01N2800/26
摘要： Verfahren zur frühzeitigen Ermittlung des Mortalitätsrisikos von Patienten auf Intensiv- oder Notfallstationen, bei dem man in einer Serum- oder Plasmaprobe eines solchen Patienten selektiv die Konzentration der Cu/Zn Superoxiddismutase (Cu/Zn SOD oder SOD-1) bestimmt und quantitativ oder semiquantitativ gemessene Konzentrationen, die über einem vorgegebenen Schwellenwert, z.B. über etwa 310 ng/ml, liegen, mit einem hohen Mortalitätsrisiko korreliert.
摘要翻译： 早期确定接受紧急或紧急护理的患者死亡风险的方法包括在血清或血浆中测量铜锌超氧化物歧化酶（SOD-1）的浓度，其中高于预定阈值的浓度与高风险相关 。
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9.发明公开VERWENDUNGEN DER CARBAMOYLPHOSPHAT SYNTHETASE 1 (CPS 1) UND IHRER FRAGMENTE FÜR DIE DIAGNOSE VON ENTZÜNDUNGSERKRANKUNGEN UND SEPSIS 有权作者：1个氨甲酰磷酸合成使用I（CPS 1）及其碎片作诊断败血症
公开(公告)号：EP1497662A1
公开(公告)日：2005-01-19
申请号：EP03725036.2
申请日：2003-04-15
IPC分类号： G01N33/68 , G01N33/569 , G01N33/573
CPC分类号： G01N33/6893 , C12Q1/34 , C12Q1/48 , G01N2333/9015 , G01N2800/26
摘要： The invention relates to the use of the carbamoyl phosphate synthetase 1 (CPS 1) and/or fragments of the N-terminal part of the CPS 1 of body fluids or body tissues, as marker peptides for diagnostic detection, and for the prognosis and control of the development of inflammations and infections, including sepsis, and liver failure in the case of multi-organ failure, or for determinations relating to inflammatory liver diseases and other liver diseases.
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10.发明公开VERFAHREN ZUR DIAGNOSE VON ENTZÜNDUNGSERKRANKUNGEN UND INFEKTIONEN MITTELS BESTIMMUNG VON LASP-1/ LAP-1 有权于诊断炎性疾病和感染的方法BY LASP-1 / LAP-1的判定
公开(公告)号：EP1493034A2
公开(公告)日：2005-01-05
申请号：EP03722485.4
申请日：2003-04-15
IPC分类号： G01N33/68 , G01N33/574 , C07K14/47 , A61K38/17
CPC分类号： G01N33/566 , G01N33/6893 , G01N33/6896 , G01N2800/26
摘要： The invention relates to a method for the early detection and identification, for a prognosis on the course, assessment of the severity and assessment during the course of therapy of inflammatory diseases and infections, in particular systemic infections similar to septicaemia and Alzheimer's disease. According to said method, the presence and/or quantity of the protein LASP-1 (SEQ ID NO:1), or the protein LAP-1 (SEQ ID NO:16), or an immunoreactive fragment of one of said proteins is determined, preferably as immunoreactivity, in a free and/or protein-bound form in a biological liquid, or optionally a tissue sample of a patient and conclusions are drawn from the presence and/or quantity of the specific proteins with regard to the existence, the expected course, the severity or the success of a therapy of the inflammatory disease or the infection.
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