发明公开
EP1489081A1 SPIRO DERIVATIVES AND ADHESION MOLECULE INHIBITORS COMPRISING THE SAME AS THE ACTIVE INGREDIENT
审中-公开
SPIRODERIVATE UNDADHÄSIONSMOLEKÜLINHIBITOREN，DIE DIESE ALS WIRKSTOFF ENTHALTEN
- 专利标题： SPIRO DERIVATIVES AND ADHESION MOLECULE INHIBITORS COMPRISING THE SAME AS THE ACTIVE INGREDIENT
- 专利标题（中）： SPIRODERIVATE UNDADHÄSIONSMOLEKÜLINHIBITOREN，DIE DIESE ALS WIRKSTOFF ENTHALTEN
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申请号： EP03715376.4申请日： 2003-03-19
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公开(公告)号： EP1489081A1公开(公告)日： 2004-12-22
- 发明人: ISHIGAKI, Takeshi , TANIGUCHI, Koji , KAINOH, Mie , MEGURO, Hiroyuki , ISHIZAKA, Yoko
- 申请人： TORAY INDUSTRIES, INC.
- 申请人地址： 2-1, Nihonbashi Muromachi 2-chome, Chuo-ku Tokyo 103-8666 JP
- 专利权人： TORAY INDUSTRIES, INC.
- 当前专利权人： TORAY INDUSTRIES, INC.
- 当前专利权人地址： 2-1, Nihonbashi Muromachi 2-chome, Chuo-ku Tokyo 103-8666 JP
- 代理机构： Kador & Partner
- 优先权： JP2002080697 20020322
- 国际公布： WO2003080611 20031002
- 主分类号： C07D471/10
- IPC分类号： C07D471/10 ; A61K31/438 ; A61P1/04 ; A61P11/02 ; A61P11/06 ; A61P13/12 ; A61P17/00 ; A61P19/02 ; A61P25/00 ; A61P29/00 ; A61P37/02 ; A61P37/08 ; A61P43/00
摘要：
Disclosed is the use of an adhesion molecule inhibitor that is effective in the prevention and treatment of inflammatory diseases caused by infiltration of leukocytes such as monocytes, lymphocytes and eosinophils, by inhibiting cell infiltration which mediates adhesion molecules, especially adhesion molecule VLA-4.
Since the spiro acid derivatives according to the present invention are excellent in the effect of inhibiting cell adhesion via adhesion molecules, especially adhesion molecule VLA-4, they are useful as therapeutic drugs against various inflammatory diseases. For example, provided are the spiro derivative and the adhesion molecule inhibitor which includes as an active ingredient the spiro derivative as shown by the below formula (18).
Since the spiro acid derivatives according to the present invention are excellent in the effect of inhibiting cell adhesion via adhesion molecules, especially adhesion molecule VLA-4, they are useful as therapeutic drugs against various inflammatory diseases. For example, provided are the spiro derivative and the adhesion molecule inhibitor which includes as an active ingredient the spiro derivative as shown by the below formula (18).
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