摘要:
Disclosed is the use of an adhesion molecule inhibitor that is effective in the prevention and treatment of inflammatory diseases caused by infiltration of leukocytes such as monocytes, lymphocytes and eosinophils, by inhibiting cell infiltration which mediates adhesion molecules, especially adhesion molecule VLA-4. Since the spiro acid derivatives according to the present invention are excellent in the effect of inhibiting cell adhesion via adhesion molecules, especially adhesion molecule VLA-4, they are useful as therapeutic drugs against various inflammatory diseases. For example, provided are the spiro derivative and the adhesion molecule inhibitor which includes as an active ingredient the spiro derivative as shown by the below formula (18).
摘要:
Prevention or therapy of inflammatory diseases caused by invasion of leukocytes such as monocytes, lymphocytes and eosinophils, by providing a substance which inhibits cell adhesion via an adhesion molecule, especially adhesion molecule VLA-4, is disclosed. A group of carboxylic acid derivatives represented by, for example, and adhesion molecule inhibitors comprising the same as an effective ingredient were provided.
摘要:
Disclosed are: a polymer for treating the surface of a medical device such as a contact lens to suppress the reduction in lubricity of the device even when the device is scrubbed; a medical device having the polymer on the surface so that the reduction in lubricity over time is suppressed; and a wetting agent containing the polymer. The polymer for treating the surface is a copolymer which is water-soluble and includes as constitutional units the following monomers A and B: monomer A: a monomer containing a (meth)acryloyl group and an ester or amide structure in a molecule, in which the ester or amide structure is not constituted by including a part of the (meth)acryloyl group; monomer B: a monomer containing a (meth)acrylamide group in a molecule and having a structure different from that of the monomer A.
摘要:
Provided are an aromatic amine compound as represented by formula (1), used for improving light extraction efficiency and color purity of an organic light-emitting element, an organic light-emitting element material containing said aromatic amine compound, an organic light-emitting element covering layer material containing said aromatic amine compound, and an organic light-emitting element containing said aromatic amine compound. The organic light-emitting element achieves high light-emitting efficiency and color reproducibility. The organic light-emitting element can be used as organic EL display, backlight source for liquid crystal display, illumination, light source for measurement devices, indication board or identificaion lamp etc. The organic light-emitting element significantly improves light extraction efficiency and has superior color purity.
摘要:
An organic light-emitting element, including a substrate, a first electrode, a light-emitting layer containing one organic or more layer film, and a light-emitting element of a second electrode. The light-emitting element is provided with a covering layer. For the organic material contained in covering layer, at least one point in the wavelength range between 430nm and 460nm the attenuation coefficient is greater than 0.10 while in the wavelength range of 460nm to 500nm its attenuation coefficient is 0.10 or below. The organic light-emitting element achieves high light-emitting efficiency and color reproducibility, and can be used as organic EL display, backlight source for liquid crystal display, illumination, light source for measurement devices, indication board or identificaion lamp etc.
摘要:
Disclosed are novel spiro compounds and their use as drugs, particularly adhesion molecule inhibitors useful in the treatment of inflammatory diseases. An example of the spiro compounds has a chemical structure represented by formula (31).
摘要:
The invention provides a light emitting device having a low driving voltage and excellent durability by a material for a light emitting device expressed by the general formula (1) :
wherein each of R 1 , R 2 , R 3 , R 4 , R 5 and R 6 may be the same or different and is selected from hydrogen, an alkyl group, and an aryl group, A represents an n-valent aromatic hydrocarbon group, B represents an alkyl group or an aryl group, X represents carbon or nitrogen, n represents a natural number from 2 to 6, and n substituents having a phenanthroline skeleton or a benzoquinoline skeleton may be the same or different.
摘要翻译:本发明提供一种通过通式(1)表示的用于发光器件的材料具有低驱动电压和优异耐久性的发光器件:其中R 1,R 2,R 3,R 4,R 5和 R 6可以相同或不同,选自氢,烷基和芳基,A表示n价的芳香族烃基,B表示烷基或芳基,X表示碳或氮,n 表示2至6的自然数,并且具有菲咯啉骨架或苯并喹啉骨架的n个取代基可以相同或不同。
摘要:
Disclosed are novel spiro derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases. The spiro derivative according to the present invention has the chemical structure, for example, represented by the following Formula (31):