发明授权
EP1489083B1 FUSED BICYCLIC PYRIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST
有权
稠合的双环吡啶衍生物作为速激肽拮抗剂的
- 专利标题: FUSED BICYCLIC PYRIDINE DERIVATIVE AS TACHYKININ RECEPTOR ANTAGONIST
- 专利标题(中): 稠合的双环吡啶衍生物作为速激肽拮抗剂的
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申请号: EP03712827.9申请日: 2003-03-24
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公开(公告)号: EP1489083B1公开(公告)日: 2007-06-06
- 发明人: SETO, Shigeki , TANIOKA, Asao , IKEDA, Makoto , IZAWA, Shigeru
- 申请人: KYORIN PHARMACEUTICAL CO., LTD.
- 申请人地址: 5, Kanda Surugadai 2-chome, Chiyoda-ku Tokyo 101-8311 JP
- 专利权人: KYORIN PHARMACEUTICAL CO., LTD.
- 当前专利权人: KYORIN PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: 5, Kanda Surugadai 2-chome, Chiyoda-ku Tokyo 101-8311 JP
- 代理机构: Vossius & Partner
- 优先权: JP2002084758 20020326
- 国际公布: WO2003080626 20031002
- 主分类号: C07D498/04
- IPC分类号: C07D498/04 ; A61K31/496 ; A61K31/551 ; A61K31/553 ; A61P1/00 ; A61P1/04 ; A61P1/08 ; A61P11/06 ; A61P11/14 ; A61P13/00 ; A61P13/02 ; A61P19/02 ; A61P25/02 ; A61P25/04 ; A61P25/06 ; A61P29/00 ; A61P43/00 ; A61P13/10
摘要:
A novel fused bicyclic pyridine derivative represented by the following general formula (1), which has an antagonistic effect on tachykinin receptors, especially on an NK1 receptor. It is a fused bicyclic pyridine derivative represented by the general formula (1): (1) (wherein rings A and B each represents a benzene ring optionally having one to three substituents (two adjacent substituents may be bonded to each other to form a ring) each independently selected among halogen atoms, optionally substituted C1-6 alkyls, and optionally substituted C1-6 alkoxys; R represents C1-6 alkylsulfonyl, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, or formyl; m is 1 or 2; n is 2 or 3; and q is 1 or 2) or a salt of the derivative.
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