发明公开
- 专利标题： OSTEOCLAST DIFFERENTIATION INHIBITORS
- 专利标题（中）： INHIBITOREN DER OSTEOKLASTENDIFFERENZIERUNG
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申请号： EP03710258.9申请日： 2003-03-06
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公开(公告)号： EP1489187A1公开(公告)日： 2004-12-22
- 发明人: KUMAGAI, Hiroyuki , SAMESHIMA, Tomohiro , MATSUFUJI, Motoko , KAWAMURA, Naoto , ISSHIKI, Kunio , INOUE, Hiroyuki , SOMENO, Tetsuya , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
- 申请人： MERCIAN CORPORATION , ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 申请人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo 104-8305 JP
- 专利权人： MERCIAN CORPORATION,ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人： MERCIAN CORPORATION,ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI
- 当前专利权人地址： 5-8, Kyobashi 1-chome Chuo-ku, Tokyo 104-8305 JP
- 代理机构： Horner, Martin Grenville
- 优先权： JP2002063046 20020308
- 国际公布： WO2003076639 20030918
- 主分类号： C12P17/18
- IPC分类号： C12P17/18 ; C12P17/14 ; C07D265/38 ; C07D498/04 ; A61K31/5383 ; A61P19/02 ; A61P19/10 ; A61P29/00 ; A61P35/00 ; A61P35/04 ; A61P43/00
摘要：
A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents -O- and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamella sp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I):
wherein X represents -O- or -CH 2 -, and R represents a hydroxyl group when X represents -O-, or a hydrogen atom when X represents -CH 2 -.
wherein X represents -O- or -CH 2 -, and R represents a hydroxyl group when X represents -O-, or a hydrogen atom when X represents -CH 2 -.
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