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公开(公告)号：EP0930310B1
公开(公告)日：2003-03-26
申请号：EP96917702.1
申请日：1996-06-17
发明人： HIRANO, Shin-ichi , MASE, Toshiyuki , AGATA, Naoki , IGUCHI, Hiroshi , MATSUMOTO, Naoki , YOSHIOKA, Takeo , TONE, Hiroshi , KUMAGAI, Hiroyuki , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
IPC分类号： C07D311/76 , A61K31/35
CPC分类号： C07D311/76
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公开(公告)号：EP0930310A1
公开(公告)日：1999-07-21
申请号：EP96917702.1
申请日：1996-06-17
发明人： HIRANO, Shin-ichi , MASE, Toshiyuki , AGATA, Naoki , IGUCHI, Hiroshi , MATSUMOTO, Naoki , YOSHIOKA, Takeo , TONE, Hiroshi , KUMAGAI, Hiroyuki , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
IPC分类号： C07D311/76 , A61K31/35
CPC分类号： C07D311/76
摘要： Compounds of the formula (I)
wherein R is a hydrogen atom or a C 1-6 alkyl group and n is an integer of 0 or 1, and pharmaceutical preparations thereof are provided. These pharmaceutical preparations are useful for the prevention or treatment of diseases associated with an abnormality in immunological regulatory function or vascularization.-
公开(公告)号：EP1489187A1
公开(公告)日：2004-12-22
申请号：EP03710258.9
申请日：2003-03-06
发明人： KUMAGAI, Hiroyuki , SAMESHIMA, Tomohiro , MATSUFUJI, Motoko , KAWAMURA, Naoto , ISSHIKI, Kunio , INOUE, Hiroyuki , SOMENO, Tetsuya , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
IPC分类号： C12P17/18 , C12P17/14 , C07D265/38 , C07D498/04 , A61K31/5383 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00
CPC分类号： C07D265/38 , C12P17/14 , C12P17/188 , C12R1/645
摘要： A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents -O- and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamella sp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I):
wherein X represents -O- or -CH 2 -, and R represents a hydroxyl group when X represents -O-, or a hydrogen atom when X represents -CH 2 -.摘要翻译： 由式（I）表示的化合物; 通过使用属于葫芦科属的微生物，制备式（I）化合物（物质F-1490）的方法，其中X表示-O-，R表示羟基; 和葫芦科（Cunninghamella sp。） 能够生产物质F-1490的F-1490菌株（FERM BP-8287）; 以及破骨细胞分化抑制剂，其含有作为活性成分的式（I）表示的化合物：其中X表示-O-或-CH2-，R表示当X表示-O-时的羟基，或氢 当X代表-CH2-时，原子。
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公开(公告)号：EP1489186A1
公开(公告)日：2004-12-22
申请号：EP03710259.7
申请日：2003-03-06
发明人： KUMAGAI, Hiroyuki , SAMESHIMA, Tomohiro , MATSUFUJI, Motoko , KAWAMURA, Naoto , SOMENO, Tetsuya , ISHIZUKA, Masaaki , TAKEUCHI, Tomio
IPC分类号： C12P17/02 , C07D493/04 , C07D303/32 , A61P17/06 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： C07D493/04 , C07D303/32 , C12P17/02 , C12P17/181 , C12R1/66
摘要： Compounds represented by formula (I) below; a process for producing the compounds by culturing a microorganism belonging to the genus Aspergillus and isolating the above-mentioned compounds from the culture; an angiogenesis inhibitory agent containing as an active ingredient the compounds; and an Aspergillus sp. F-1491 (FERM BP-8288) strain capable of producing the compounds.
In formula (I), R represents a methyl group or an ethyl group, R 1 represents a hydrogen atom, a chlorine atom, a hydroxyl group or a methoxy group, R 2 represents a hydroxyl group, or R 1 and R 2 taken together form an epoxy ring structure.摘要翻译： 由以下式（I）表示的化合物; 通过培养属于曲霉属的微生物并从培养物中分离上述化合物来生产所述化合物的方法; 含有化合物作为有效成分的血管生成抑制剂; 和曲霉属（Aspergillus sp。）。 能够产生这些化合物的F-1491（FERM BP-8288）菌株。 式（I）中，R表示甲基或乙基，R 1表示氢原子，氯原子，羟基或甲氧基，R 2表示羟基，或R 1和R 2一起形成环氧环 结构体。
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5.发明授权CONAGENIN FOR THE TREATMENT OF ULCEROUS COLITIS AND/OR CROHN'S DISEASE 失效Conagenin用于治疗溃疡性结肠炎和/或节段性回肠炎
公开(公告)号：EP0987022B1
公开(公告)日：2006-01-25
申请号：EP98912719.6
申请日：1998-04-08
发明人： ISHIZUKA, Masaaki , MAEDA, Kenji , TAKEUCHI, Tomio , SHIRAISHI, Tadayoshi , FUKUSHIMA, Masakazu
IPC分类号： A61K31/198 , A61P1/04
CPC分类号： A61K31/198 , Y10S514/885 , Y10S514/925 , Y10S514/926
摘要： Preventives and remedies for ulcerous colitis and/or Crohn's disease containing as the active ingredient conagenin or a pharmaceutically acceptable salt thereof and having prominent therapeutic effects and a high safety.
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公开(公告)号：EP0783884B1
公开(公告)日：2002-09-04
申请号：EP95934300.5
申请日：1995-10-13
IPC分类号： A61K31/195
CPC分类号： A61K31/475 , A61K31/198 , A61K31/505 , A61K31/675 , Y10S514/867 , A61K31/195 , A61K2300/00
摘要： A preventive and remedy for diarrhea containing conagenin or a salt thereof as the active ingredient, capable of intensely suppressing particularly a diarrheic symptom accompanying the administration of cancer chemotherapeutics to thereby permit perennial cancer chemotherapy, and capable of preventing exhaustion of the physical strength of a patient to thereby enhance the therapeutic effect.
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公开(公告)号：EP0783884A1
公开(公告)日：1997-07-16
申请号：EP95934300.5
申请日：1995-10-13
申请人： ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI , TAIHO PHARMACEUTICAL COMPANY LIMITED , KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA
IPC分类号： A61K31/195
CPC分类号： A61K31/475 , A61K31/198 , A61K31/505 , A61K31/675 , Y10S514/867 , A61K31/195 , A61K2300/00
摘要： A preventive and remedy for diarrhea containing conagenin or a salt thereof as the active ingredient, capable of intensely suppressing particularly a diarrheic symptom accompanying the administration of cancer chemotherapeutics to thereby permit perennial cancer chemotherapy, and capable of preventing exhaustion of the physical strength of a patient to thereby enhance the therapeutic effect.
摘要翻译： 作为活性成分的含有凝集素或其盐的腹泻的预防和补救措施，能够特别强烈地抑制伴随癌症化学治疗剂的施用的腹泻症状，从而允许多年生癌症化学疗法，并且能够防止患者身体的疲劳疲劳 从而增强治疗效果。
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8.发明公开NOVEL ANTIBIOTICS WITH IMMUNOSUPPRESSIVE ACTIVITY, DELAMINOMYCINS, AND PRODUCTION THEREOF 失效使用抗生素麻省理工学院免疫印度尼西亚，德国HERSTELLUNG的DELAMINOMYCINE。
公开(公告)号：EP0647625A1
公开(公告)日：1995-04-12
申请号：EP93913563.8
申请日：1993-06-22
发明人： ISHIZUKA, Masaaki , UENO, Mitsuhiro , IINUMA, Hironobu , NAGANAWA, Hiroshi , HAMADA, Masa , MAEDA, Kenji , TAKEUCHI, Tomio
IPC分类号： C07D207/36 , C07D209/96 , C12P17/10 , A61K31/40 , C07D207/40
CPC分类号： C07D207/38 , C07D207/36 , C07D209/96 , C12P17/10
摘要： Delaminomycins A, B and C, represented by general formula (I) or (I'), or salts thereof, delaminomycins A2, B2 and C2, represented by general formula (II), and sulfates of delaminomycins A2 to C2, represented by general formula (III), or salts thereof. The delaminomycins selectively inhibit T cells, have the activity of inhibiting the growth of certain cancer cells, and are antibacterial.
摘要翻译： 由通式（I）或（I'）表示的Delaminomycins A，B和C或其盐，由通式（II）表示的脱氨基霉素A2，B2和C2，以及由一般式（II）表示的脱氨霉素A2至C2的硫酸盐 式（III）或其盐。 去霉素选择性抑制T细胞，具有抑制某些癌细胞生长的活性，并且是抗菌的。
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9.发明公开PREVENTIVES AND REMEDIES FOR ULCEROUS COLITIS AND/OR CROHN'S DISEASE 失效CONAGENIN ZUR BEHANDLUNG VON ULZERATIVER KOLITIS UND / ODER MORBUS CROHN
公开(公告)号：EP0987022A1
公开(公告)日：2000-03-22
申请号：EP98912719.6
申请日：1998-04-08
发明人： ISHIZUKA, Masaaki , MAEDA, Kenji , TAKEUCHI, Tomio , SHIRAISHI, Tadayoshi , FUKUSHIMA, Masakazu
IPC分类号： A61K31/195
CPC分类号： A61K31/198 , Y10S514/885 , Y10S514/925 , Y10S514/926
摘要： Preventives and remedies for ulcerous colitis and/or Crohn's disease containing as the active ingredient conagenin or a pharmaceutically acceptable salt thereof and having prominent therapeutic effects and a high safety.
摘要翻译： 溃疡性结肠炎和/或克罗恩病的预防和治疗包含作为活性成分的连接蛋白或其药学上可接受的盐，具有突出的治疗效果和高安全性。
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10.发明公开TUMOR RADIOSENSITIZATION AND/OR CHEMOPOTENTIATION USING ISOCOUMARIN DERIVATIVES 审中-公开用异香豆甙衍生物进行肿瘤放射增敏和/或化学方法
公开(公告)号：EP1363667A1
公开(公告)日：2003-11-26
申请号：EP01918607.1
申请日：2001-03-13
发明人： REIMER, Corinne , KUFE, Donald, W. , AGATA, Naoki , TAKEUCHI, Tomio , ISHIZUKA, Masaaki , YOSHIOKA, Takeo , KUMAGAI, Hiroyuki , WEICHSELBAUM, Ralph, R.
IPC分类号： A61K41/00
CPC分类号： A61K41/0038
摘要： A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation properties are employed in a combination treatment with ionizing radiation and/or chemotherapy.
摘要翻译： 提供了用于增强化疗和/或放射治疗动物特别是人的癌症的功效的方法，其中某些表现出独特的放射增敏活性和/或化学增强性的异香豆素衍生物用于与电离辐射和/ 或化疗。
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