发明授权
- 专利标题： COMPOUNDS THAT STIMULATE GLUCOSE UTILIZATION AND METHODS OF USE
- 专利标题（中）： 葡萄糖的利用化合物刺激及使用方法
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申请号： EP03745384.2申请日： 2003-03-31
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公开(公告)号： EP1499580B1公开(公告)日： 2012-03-28
- 发明人: LOPASCHUK, Gary, David , VEDERAS, John, Christopher , DYCK, Jason, Roland
- 申请人： The Governors of the University of Alberta
- 申请人地址： 222 Campus Tower, 8625-112 Street Edmonton, Alberta T6G 2E1 CA
- 专利权人： The Governors of the University of Alberta
- 当前专利权人： The Governors of the University of Alberta
- 当前专利权人地址： 222 Campus Tower, 8625-112 Street Edmonton, Alberta T6G 2E1 CA
- 代理机构： Vossius & Partner
- 优先权： PCT/IB02/02525 20020401; US112041 20020401; US181274 20020711; US313990 20021205
- 国际公布： WO2003082800 20031009
- 主分类号： C07C69/757
- IPC分类号： C07C69/757 ; C07C233/63 ; C07C217/08 ; A61K31/215 ; A61K31/164 ; A61K31/13 ; A61P3/08
摘要：
The invention provides novel compounds of the Formula (I) that stimulate rates of glucose oxidation in myocardial cells wherein W, Cyc, p, , X, Z, R, K-, R, R1, R2, R3,R4, I and n are as defined for Formula (I) herein. The invention also relates to pharmaceutical compositions comprising compounds capable of stimulation of glucose Oxidation, methods for increasing glucose oxidation rates in myocardial cells, and methods of treatment of myocardial ischemia.
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