发明公开
EP1516932A1 Poxvirus with targeted infection specificity
有权
Pockenviren mit zielgerichteterInfektionsspezifität
- 专利标题： Poxvirus with targeted infection specificity
- 专利标题（中）： Pockenviren mit zielgerichteterInfektionsspezifität
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申请号： EP04077339.2申请日： 2001-04-12
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公开(公告)号： EP1516932A1公开(公告)日： 2005-03-23
- 发明人: Balloul, Jean-Marc , Paul, Stéphane , Geist, Michel
- 申请人： TRANSGENE S.A.
- 申请人地址： 11, rue de Molsheim 67000 Strasbourg FR
- 专利权人： TRANSGENE S.A.
- 当前专利权人： TRANSGENE S.A.
- 当前专利权人地址： 11, rue de Molsheim 67000 Strasbourg FR
- 代理机构： Ahner, Francis
- 优先权： EP00440109 20000414; US246080P 20001107; EP01440009 20010122
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C12N15/62 ; C12N7/04 ; C07K14/705 ; A61K35/76 ; A61K48/00
摘要：
The present invention concerns a poxviral particle having a targeted infection specificity conferred by an heterologous ligand moiety present at the surface of said poxviral particle and capable of specifically recognizing and binding to an anti-ligand molecule localized at the surface of target cells. The present invention further relates to a vector comprising a nucleotide sequence encoding a chimeric polypeptide including such an heterologous ligand moiety and all or part of a natural poxviral surface polypeptide. The present invention additionally concerns compositions comprising said poxviral particle or said vector as well as their use for therapeutic and prophylactic purposes. The invention is of very special interest in gene therapy applications, in particular in preventing or treating cancer in mammals.
公开/授权文献
- EP1516932B1 Poxvirus with targeted infection specificity 公开/授权日：2008-10-15
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