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288 条记录 (耗时 0.038 秒)

    MULTIFUNCTIONAL CYTOKINES
    1.
    发明授权
    MULTIFUNCTIONAL CYTOKINES 有权
    多功能细胞因子

    公开(公告)号：EP1648931B1

    公开(公告)日：2011-02-09

    申请号：EP04763359.9

    申请日：2004-07-20

    申请人： TRANSGENE S.A.

    发明人： PAUL, Stéphane

    IPC分类号： C07K14/54 ,  C07K14/55 ,  C12N15/62 ,  C12N15/861 ,  A61K48/00 ,  A61K38/19 ,  C07K14/57

    CPC分类号： C07K14/54 ,  A61K38/00 ,  C07K14/52 ,  C07K14/5418 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/57 ,  C07K2319/00 ,  C12N15/62 ,  C12N2799/022

    摘要： The present invention relates to a novel fusion protein with the formula X-Y, or Y-X, wherein X represents a first immunoregulating polypeptide and Y represents a second immunoregulating polypeptide different from X. The present invention also relates to a nucleic acid molecule encoding such a fusion protein and a vector comprising such a nucleic acid molecule. The present invention also provides infectious viral particles and host cells comprising such a nucleic acid molecule or such a vector as well as a process for producing such infectious viral particles. The present invention also relates to a method for recombinantly producing such a fusion protein. Finally, the present invention also provides a pharmaceutical composition comprising such a fusion protein, a nucleic acid molecule, a vector, infectious viral particles and a host cell as well as the therapeutic use thereof.

    HPV-18-BASED PAPILLOMAVIRUS VACCINE
    5.
    发明公开
    HPV-18-BASED PAPILLOMAVIRUS VACCINE 审中-公开
    基于HPV-18的PAPILLOMAVIRUS疫苗

    公开(公告)号：EP2013229A2

    公开(公告)日：2009-01-14

    申请号：EP07724304.6

    申请日：2007-04-17

    申请人： TRANSGENE S.A.

    发明人： ROOKE, Ronald ,  PAUL, Stéphane

    IPC分类号： C07K14/025

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5256 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2710/24143

    摘要： Compositions containing one or more early polypeptide(s) of human papillomavirus (HPV)-18 or a nucleic acid encoding one or more early polypeptide(s) of HPV-18 are useful for preventing or treating an infection or a pathological condition caused by at least one papillomavirus other than HPV-18; the subject compositions are of very special interest in immunotherapy, in particular for preventing or treating HPV persistent infections that might promote cervical intraepithelial neoplasia (CIN) and ultimately cervical cancer.

    摘要翻译： 本发明涉及包含一种或多种人乳头瘤病毒（HPV）-18的早期多肽或编码HPV-18的一种或多种早期多肽的核酸的组合物用于制造药物 用于预防或治疗由至少一种不同于HPV-18的乳头瘤病毒引起的感染或病理状况。 本发明对免疫治疗特别感兴趣，特别是在预防或治疗可能导致宫颈上皮内瘤变（CIN）并最终导致宫颈癌的HPV持续感染方面。

    VECTEURS ADENOVIRAUX RECOMBINANTS COMPRENANT UNE SEQUENCE D'EPISSAGE
    7.
    发明授权
    VECTEURS ADENOVIRAUX RECOMBINANTS COMPRENANT UNE SEQUENCE D'EPISSAGE 失效
    重组腺病毒载体甲SPLEISSEQUENZ CONTAIN

    公开(公告)号：EP0988391B1

    公开(公告)日：2004-12-15

    申请号：EP98928412.0

    申请日：1998-06-02

    申请人： TRANSGENE S.A.

    发明人： MEHTALI, Majid ,  LEROY, Pierre ,  MICHOU, Anne-Isabelle

    IPC分类号： C12N15/86 ,  C12N5/10 ,  A61K48/00 ,  C12N15/26 ,  C07K14/55 ,  C12N15/12 ,  C07K14/745

    CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2710/10343 ,  C12N2830/42 ,  C12N2840/44

    摘要： The invention concerns a recombinant adenoviral vector driving from an adenovirus genome at least by deleting all or part of the E1 region, said adenoviral vector comprising an expression cassette of a gene of interest placed under the control of elements necessary for its expression in a host cell or a host organism, said elements required for its expression including at least a splicing sequence. The invention is characterised in that said splicing sequence is derived from a eukaryotic nuclear gene selected among the ovalbumen genes, α or β-globine, collagen and factor VIII of mammals or a synthetic splicing sequence. The invention also concerns a host cell and an infectious viral particle comprising such a vector, a method for preparing such a particle and their therapeutic or prophylactic use. The invention further concerns a pharmaceutical composition containing said adenoviral vector, said host cell or said viral particle.

    TARGETING PEPTIDES
    9.
    发明公开
    TARGETING PEPTIDES 审中-公开
    目标肽

    公开(公告)号：EP1254163A2

    公开(公告)日：2002-11-06

    申请号：EP01916958.0

    申请日：2001-01-26

    申请人： TRANSGENE S.A.

    发明人： SCHUGART, Klaus ,  RASSMUSSEN, Ulla ,  SCHREIBER, Valérie

    IPC分类号： C07K7/08 ,  C07K5/08

    CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K48/00 ,  C07K7/08

    摘要： The present invention relates to targeting peptides and more specifically peptides that target heart and various tumors as well as to their use for targeting. The present invention also provides a composition comprising at least one therapeutic agent and at least one peptide of the invention or, alternatively, a nucleic acid molecule encoding such a peptide as well as its use for the preparation of a drug intended for gene transfer.