发明授权
EP1517899B1 BROADSPECTRUM SUBSTITUTED BENZISOXAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS
有权
取代的BENZISOXAZOLSULFONAMIDEBREITBÄNDIGERHIV蛋白酶抑制效果
- 专利标题： BROADSPECTRUM SUBSTITUTED BENZISOXAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS
- 专利标题（中）： 取代的BENZISOXAZOLSULFONAMIDEBREITBÄNDIGERHIV蛋白酶抑制效果
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申请号： EP03735707.6申请日： 2003-05-16
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公开(公告)号： EP1517899B1公开(公告)日： 2007-08-29
- 发明人: SURLERAUX, Dominique, Louis, Nestor, Ghislain , VERGOUWEN, Bernhard, Joanna, Bernard , DE KOCK, Herman, Augustinus
- 申请人： Tibotec Pharmaceuticals Ltd.
- 申请人地址： Eastgate Village Eastgate Little Island Co Cork IE
- 专利权人： Tibotec Pharmaceuticals Ltd.
- 当前专利权人： Tibotec Pharmaceuticals Ltd.
- 当前专利权人地址： Eastgate Village Eastgate Little Island Co Cork IE
- 代理机构： Daelemans, Frank F.R.
- 优先权： EP02076957 20020517
- 国际公布： WO2003097616 20031127
- 主分类号： C07D261/20
- IPC分类号： C07D261/20 ; C07D493/04 ; C07D413/12 ; C07D417/12 ; A61K31/423 ; A61K31/427 ; A61P31/18
摘要：
The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs esters and metabolites thereof. It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.
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