发明公开
EP1518933A1 Vectors and methods for gene transfer to cells
失效
Zenen的Vektoren und Methoden zum Gentransfer
- 专利标题： Vectors and methods for gene transfer to cells
- 专利标题（中）： Zenen的Vektoren und Methoden zum Gentransfer
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申请号： EP04028530.6申请日： 1996-11-27
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公开(公告)号： EP1518933A1公开(公告)日： 2005-03-30
- 发明人: Wickham, Thomas J. , Kovesdi, Imre , Brough, Douglas E.
- 申请人： GENVEC, INC.
- 申请人地址： 12111 Parklawn Drive Rockville, MD 20852 US
- 专利权人： GENVEC, INC.
- 当前专利权人： GENVEC, INC.
- 当前专利权人地址： 12111 Parklawn Drive Rockville, MD 20852 US
- 代理机构： HOEGER, STELLRECHT & PARTNER Patentanwälte
- 优先权： US563368 19951128; US700846 19960821; US701124 19960821
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C07K14/075 ; C12N7/01 ; A61K48/00
摘要：
The present invention provides a chimeric adenovirus coat protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence. Such a chimeric adenovirus coat protein according to the invention is able to direct entry into cells of a vector comprising the coat protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus coat protein rather than the chimeric adenovirus coat protein. The chimeric coat protein preferably is a fiber, hexon, or penton protein, The present invention also provides an adenoviral vector that comprises the chimeric adenovirus coat protein, as well as methods of constructing and using such a vector.
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