发明公开
EP1532453A4 MATERNAL ANTIBODIES AS FETAL CELL MARKERS TO IDENTIFY AND ENRICH FETAL CELLS FROM MATERNAL BLOOD
有权
作为标记物时母源抗体胎儿细胞识别和富集胎儿细胞从母体血液
- 专利标题: MATERNAL ANTIBODIES AS FETAL CELL MARKERS TO IDENTIFY AND ENRICH FETAL CELLS FROM MATERNAL BLOOD
- 专利标题(中): 作为标记物时母源抗体胎儿细胞识别和富集胎儿细胞从母体血液
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申请号: EP03722092申请日: 2003-05-30
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公开(公告)号: EP1532453A4公开(公告)日: 2008-03-05
- 发明人: BOHMER RALPH
- 申请人: GENETIC TECHNOLOGIES LTD
- 专利权人: GENETIC TECHNOLOGIES LTD
- 当前专利权人: GENETIC TECHNOLOGIES LTD
- 优先权: US38517002 2002-05-31
- 主分类号: G01N33/53
- IPC分类号: G01N33/53 ; C12N5/00 ; C12N5/06 ; C12Q1/04 ; G01N21/78 ; G01N33/543 ; G01N33/567 ; G01N33/569 ; G01N33/68 ; G01N33/80
摘要:
The present invention provides methods for identifying and/or enriching fetal cells from maternal blood, using as fetal cell markers the antibodies that the mother produces against paternally inherited fetal antigens. The fetal cell-maternal antibody complexes are identified and isolated using labelled agents that bind to the maternal antibodies. The present invention also provides fetal cells, isolated by use of said maternal antibodies, as a source of fetal DNA for prenatal genetic diagnosis of the fetus.
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