发明公开
- 专利标题： ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS
- 专利标题（中）： 免疫学特异性结合于TRAIL受体的抗体
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申请号： EP03788476.4申请日： 2003-08-15
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公开(公告)号： EP1534336A2公开(公告)日： 2005-06-01
- 发明人: SALCEDO, Theodora , RUBEN, Steven, M. , ROSEN, Craig, A. , ALBERT, Vivian, A.
- 申请人： Human Genome Sciences, Inc.
- 申请人地址： 9410 Key West Avenue Rockville, MD 20850 US
- 专利权人： Human Genome Sciences, Inc.
- 当前专利权人： Human Genome Sciences, Inc.
- 当前专利权人地址： 9410 Key West Avenue Rockville, MD 20850 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US403382P 20020815; US425730P 20021113; US468050P 20030506
- 国际公布： WO2004016753 20040226
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00
摘要：
The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
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