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公开(公告)号：EP1534336A2
公开(公告)日：2005-06-01
申请号：EP03788476.4
申请日：2003-08-15
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2878 , A61K39/39558 , A61K2039/505 , C07K2317/622 , C07K2317/73 , C07K2317/92 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体例如用于预防和治疗癌症和其他增殖性疾病。 本发明还涉及编码抗TR4抗体的核酸分子，包含这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性病症的方法和组合物，所述方法和组合物包含向动物，优选人施用有效量的一种或多种抗体或片段 或其变体或相关分子，其免疫特异性结合TRAIL受体TR4。
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公开(公告)号：EP1572874A3
公开(公告)日：2005-12-07
申请号：EP02736661.6
申请日：2002-05-07
发明人： SALCEDO, Theodora , RUBEN, Steven, M. , ROSEN, Craig, A. , ALBERT, Vivian, R. , DOBSON, Clarie Louise , VAUGHAN, Tristan John
IPC分类号： C12N1/00
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公开(公告)号：EP1572874B1
公开(公告)日：2013-09-18
申请号：EP02736661.6
申请日：2002-05-07
发明人： SALCEDO, Theodora , RUBEN, Steven M. , ROSEN, Craig A. , ALBERT, Vivian R. , DOBSON, Clarie Louise , VAUGHAN, Tristan John
CPC分类号： C07K16/30 , A61K31/00 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K2317/565 , C07K2317/622 , A61K2300/00
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公开(公告)号：EP1572874A2
公开(公告)日：2005-09-14
申请号：EP02736661.6
申请日：2002-05-07
发明人： SALCEDO, Theodora , RUBEN, Steven, M. , ROSEN, Craig, A. , ALBERT, Vivian, R. , DOBSON, Clarie Louise , VAUGHAN, Tristan John
IPC分类号： C12N1/00
CPC分类号： C07K16/30 , A61K31/00 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/2878 , C07K2317/565 , C07K2317/622 , A61K2300/00
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors, and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating, or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.
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公开(公告)号：EP1339426A2
公开(公告)日：2003-09-03
申请号：EP01273517.1
申请日：2001-11-07
IPC分类号： A61K39/00
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptors. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TRAIL receptor antibodies, vectors, and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor.
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公开(公告)号：EP1633316A2
公开(公告)日：2006-03-15
申请号：EP04775943.6
申请日：2004-05-05
发明人： SALCEDO, Theodora , ROSEN, Craig, A. , ALBERT, Vivian, R. , HUMPHREYS, Robin , VAUGHAN, Tristan, John
IPC分类号： A61K8/18
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/30 , C07K2317/56 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/30
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.
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公开(公告)号：EP1465925A2
公开(公告)日：2004-10-13
申请号：EP02797420.3
申请日：2002-12-19
发明人： SALCEDO, Theodora , ALBERT, Vivian, R. , ROSEN, Craig, A. , HUMPHREYS, Robin , VAUGHAN, Tristan, John
IPC分类号： C07K16/00
CPC分类号： A61K45/06 , A61K2039/505 , C07K16/2878 , C07K16/30 , C07K2317/565 , C07K2317/622 , C07K2317/73
摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, for example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.
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