发明公开
EP1541558A4 HETEROCYCLIC COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY
有权
与HIV整合酶的锁定效果杂环CONNECTION
- 专利标题: HETEROCYCLIC COMPOUND HAVING HIV INTEGRASE INHIBITORY ACTIVITY
- 专利标题(中): 与HIV整合酶的锁定效果杂环CONNECTION
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申请号: EP03795216申请日: 2003-08-11
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公开(公告)号: EP1541558A4公开(公告)日: 2005-08-17
- 发明人: MURAI HITOSHI , ENDO TAKESHI , KUROSE NORIYUKI , TAISHI TERUHIKO , YOSHIDA HIROSHI
- 申请人: SHIONOGI & CO
- 专利权人: SHIONOGI & CO
- 当前专利权人: SHIONOGI & CO
- 优先权: JP2002235582 2002-08-13; JP2002245772 2002-08-26; JP2003121726 2003-04-25; JP2003270863 2003-07-04
- 主分类号: A61P31/18
- IPC分类号: A61P31/18 ; A61P37/04 ; A61P43/00 ; C07D215/48 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D405/12 ; C07D413/12 ; C07D417/06 ; C07D417/12 ; C07D471/04 ; C07D491/052 ; C07D493/04 ; A61K31/4375 ; A61K31/47 ; A61K31/4709 ; A61K31/496 ; A61K31/5377
摘要:
A compound having antiviral activity, specifically a heterocyclic compound having HIV integrase inhibitory activity; and a medicine containing the compound, especially an anti-HIV drug. The compound is a compound represented by the formula (I): (I) [wherein B1 is -C(R2)= or -N=; R1' is hydrogen, etc.; one of R1 and R2 is a group represented by the formula -Z1-Z2-Z3-R5 (wherein Z1 and Z3 each independently is a single bond, optionally substituted alkylene, etc.; Z2 is a single bond, optionally substituted alkylene, etc.; and R5 is optionally substituted aryl, optionally substituted heteroaryl, etc.) and the other is hydrogen; and -A1- is -C(-Y)=C(-RA)-C(-R3)=C(-R4)- (wherein Y is -OH, etc.; RA is -COR7 (R7 is hydroxy, etc.), etc.; and one of R3 and R4 is carboxy, etc. and the other is hydrogen, etc.), etc.], a prodrug of the compound, a pharmaceutically acceptable salt of either, or a solvate of any of these.
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