公开(公告)号：EP1950212A4

公开(公告)日：2010-08-04

申请号：EP06822311

申请日：2006-10-26

申请人： SHIONOGI & CO

发明人： YOSHIDA HIROSHI ,  KAWASUJI TAKASHI ,  TAISHI TERUHIKO ,  TAODA YOSHIYUKI

IPC分类号： A61K31/403 ,  A61K31/495 ,  A61K31/50 ,  A61K31/519 ,  C07D239/00 ,  C07D241/36 ,  C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00

CPC分类号： C07F9/6561 ,  C07D471/04 ,  C07D471/14 ,  C07D471/20 ,  C07D498/14

公开(公告)号：EP1874117A4

公开(公告)日：2009-12-30

申请号：EP06758843

申请日：2006-04-28

申请人： SMITHKLINE BEECHAM CORP ,  SHIONOGI & CO

发明人： JOHNS BRIAN ALVIN ,  KAWASUJI TAKASHI ,  TAISHI TERUHIKO ,  TAODA YOSHIYUKI

IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/495 ,  A61K31/50 ,  C07D239/00 ,  C07D241/36 ,  C07D471/00 ,  C07D487/00 ,  C07D495/00 ,  C07D497/00

CPC分类号： C07D498/14 ,  A61K9/0053 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/551 ,  A61K45/06 ,  C07D471/04 ,  C07D471/14 ,  C07D471/22 ,  C07D498/04 ,  C07D498/20 ,  C07D498/22

摘要： The present invention is to provide a novel compound shown below, having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof.

公开(公告)号：EP1714966A4

公开(公告)日：2008-01-02

申请号：EP05704349

申请日：2005-02-02

申请人： SHIONOGI & CO

发明人： TAISHI TERUHIKO ,  TADA YUKIO

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61K31/5377 ,  A61K31/541 ,  A61P31/12 ,  A61P31/18 ,  A61P43/00

CPC分类号： C07D471/04

摘要： [PROBLEMS] To provide a novel compound having antiviral activity, especially HIV integrase inhibitory activity; and a medicine, in particular, an anti-HIV drug, which contains the compound. [MEANS FOR SOLVING PROBLEMS] The compound is one represented by the formula (I) [wherein R1 is optionally substituted aralkyl; R2 and R3 each independently is hydrogen, optionally substituted alkyl, etc. (provided that the substituent(s) with which the alkyl is 'optionally substituted' are noncyclic groups); and R4 is hydrogen, optionally substituted carboxy, etc.] or a salt thereof.

公开(公告)号：EP1541558A4

公开(公告)日：2005-08-17

申请号：EP03795216

申请日：2003-08-11

申请人： SHIONOGI & CO

发明人： MURAI HITOSHI ,  ENDO TAKESHI ,  KUROSE NORIYUKI ,  TAISHI TERUHIKO ,  YOSHIDA HIROSHI

IPC分类号： A61P31/18 ,  A61P37/04 ,  A61P43/00 ,  C07D215/48 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D491/052 ,  C07D493/04 ,  A61K31/4375 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377

CPC分类号： C07D215/48 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/04 ,  C07D493/04

摘要： A compound having antiviral activity, specifically a heterocyclic compound having HIV integrase inhibitory activity; and a medicine containing the compound, especially an anti-HIV drug. The compound is a compound represented by the formula (I): (I) [wherein B1 is -C(R2)= or -N=; R1' is hydrogen, etc.; one of R1 and R2 is a group represented by the formula -Z1-Z2-Z3-R5 (wherein Z1 and Z3 each independently is a single bond, optionally substituted alkylene, etc.; Z2 is a single bond, optionally substituted alkylene, etc.; and R5 is optionally substituted aryl, optionally substituted heteroaryl, etc.) and the other is hydrogen; and -A1- is -C(-Y)=C(-RA)-C(-R3)=C(-R4)- (wherein Y is -OH, etc.; RA is -COR7 (R7 is hydroxy, etc.), etc.; and one of R3 and R4 is carboxy, etc. and the other is hydrogen, etc.), etc.], a prodrug of the compound, a pharmaceutically acceptable salt of either, or a solvate of any of these.