发明公开
- 专利标题： PYRROLOTRIAZINE KINASE INHIBITORS
- 专利标题（中）： 吡咯并三嗪激酶抑制剂
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申请号： EP03767116.1申请日： 2003-08-04
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公开(公告)号： EP1543009A1公开(公告)日： 2005-06-22
- 发明人: BHIDE, Rajeev, S. , BORZILLERI, Robert, M.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： P.O. Box 4000,Route 206 and Provinceline Road Princeton, NJ 08543-4000 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： P.O. Box 4000,Route 206 and Provinceline Road Princeton, NJ 08543-4000 US
- 代理机构： VOSSIUS & PARTNER
- 优先权： US400572P 20020802
- 国际公布： WO2004013145 20040212
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/53 ; A61P13/08 ; A61P29/00 ; A61P37/00
摘要：
The present invention provides compounds of formula I, (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2 and FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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