发明公开
- 专利标题： LIPOPHILIC DIESTERS OF CHELATING AGENT FOR INHIBITION OF ENZYME ACTIVITY
- 专利标题（中）： 上抑制酶活性螯合剂亲脂性二酯
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申请号： EP03710190.4申请日： 2003-03-16
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公开(公告)号： EP1546085A2公开(公告)日： 2005-06-29
- 发明人: STRIEM, Sarina , FRIEDMAN, Jonathan, Eduard , REZNITSKY-COHEN, Dalia , KOZAK, Alexander
- 申请人： D-Pharm Ltd.
- 申请人地址： Kiryat Weizmann Science Park 76326 Rehovot IL
- 专利权人： D-Pharm Ltd.
- 当前专利权人： D-Pharm Ltd.
- 当前专利权人地址： Kiryat Weizmann Science Park 76326 Rehovot IL
- 代理机构： VOSSIUS & PARTNER
- 优先权： IL15192102 20020925
- 国际公布： WO2004028443 20040408
- 主分类号： C07C229/00
- IPC分类号： C07C229/00 ; C07C249/00 ; C07C381/00 ; C07C205/00 ; C07C291/00 ; C07C233/00 ; C07C211/00 ; C07C335/00
摘要：
The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) for inhibition of proteolytic activities of certain metalloproteinases and of calpain. The invention further relates to methods for preventing, treating or managing MMP-related and calpain-related diseases or disorders in mammals comprising administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of said lipophilic diesters of the chelating agent BAPTA.
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