公开(公告)号：EP1546085A2

公开(公告)日：2005-06-29

申请号：EP03710190.4

申请日：2003-03-16

申请人： D-Pharm Ltd.

发明人： STRIEM, Sarina ,  FRIEDMAN, Jonathan, Eduard ,  REZNITSKY-COHEN, Dalia ,  KOZAK, Alexander

IPC分类号： C07C229/00 ,  C07C249/00 ,  C07C381/00 ,  C07C205/00 ,  C07C291/00 ,  C07C233/00 ,  C07C211/00 ,  C07C335/00

CPC分类号： A61K31/225

摘要： The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) for inhibition of proteolytic activities of certain metalloproteinases and of calpain. The invention further relates to methods for preventing, treating or managing MMP-related and calpain-related diseases or disorders in mammals comprising administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of said lipophilic diesters of the chelating agent BAPTA.

公开(公告)号：EP1546085B1

公开(公告)日：2012-09-05

申请号：EP03710190.4

申请日：2003-03-16

申请人： D-Pharm Ltd.

发明人： STRIEM, Sarina ,  FRIEDMAN, Jonathan, Eduard ,  REZNITSKY-COHEN, Dalia ,  KOZAK, Alexander

IPC分类号： C07C229/00 ,  C07C249/00 ,  C07C381/00 ,  C07C205/00 ,  C07C291/00 ,  C07C233/00 ,  C07C211/00 ,  C07C335/00 ,  A61K31/225 ,  A61P35/00 ,  A61P35/04

CPC分类号： A61K31/225