发明公开
- 专利标题： NACHWEIS VON TSH-REZEPTOR-AUTOANTIKÖRPERN MIT AFFINITÄTSGEREINIGTEN ANTIKÖRPERN
- 专利标题（英）： Identification of tsh receptor autoantibodies using affinity-purified antibodies
- 专利标题（中）： TSH受体自身抗体与亲和纯化抗体检测
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申请号： EP03775275.5申请日： 2003-10-31
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公开(公告)号： EP1565492A1公开(公告)日： 2005-08-24
- 发明人: BERGMANN, Andreas , COSTAGLIOLA, Sabine , VASSART, Gilbert
- 申请人： B.R.A.H.M.S Aktiengesellschaft
- 申请人地址： Neuendorfstrasse 25 16761 Hennigsdorf DE
- 专利权人： B.R.A.H.M.S Aktiengesellschaft
- 当前专利权人： B.R.A.H.M.S Aktiengesellschaft
- 当前专利权人地址： Neuendorfstrasse 25 16761 Hennigsdorf DE
- 代理机构： Andrae, Steffen
- 优先权： DE10255144 20021126
- 国际公布： WO2004048415 20040610
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; G01N33/566 ; G01N33/564 ; G01N33/76
摘要：
The invention relates to the use of affinity-purified polyclonal human autoantibodies against the TSH receptor (TSHR-Auto-Ab), obtained from the serum of Graves'disease patients, which have been purified to obtain biochemical homogeneity and comprise a specific activity of at least 1 IU/mg protein (human immunoglobulin) and/or the use of animal antibodies, which compete with the former for the binding sites of a functional human TSH receptor, as a specific binding reagent in an immunological determination method for the clinical identification of autoantibodies against the TSH receptor (TSHR-Auto-Ab) in a sample of a biological fluid of a patient to be examined for Graves'disease.
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