发明公开
- 专利标题： POLYMERIC BORONIC ACID DERIVATIVES AS LIPASE INHIBITORS
- 专利标题（中）： 聚合物硼酸衍生物作为脂肪酶抑制剂
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申请号： EP03768974.2申请日： 2003-11-19
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公开(公告)号： EP1578816A1公开(公告)日： 2005-09-28
- 发明人: HUVAL, Chad Cori , LI, Xinhua , HOLMES-FARLEY, Stephen, Randall , DHAL, Pradeep, K.
- 申请人： GENZYME CORPORATION
- 申请人地址： 500 Kendall Street Cambridge, MA 02142 US
- 专利权人： GENZYME CORPORATION
- 当前专利权人： GENZYME CORPORATION
- 当前专利权人地址： 500 Kendall Street Cambridge, MA 02142 US
- 代理机构： Wilson, Alan Stuart
- 优先权： US427518P 20021119
- 国际公布： WO2004046211 20040603
- 主分类号： C08F20/00
- IPC分类号： C08F20/00
摘要：
Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.
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