发明公开
- 专利标题： INDOLE DERIVATIVES AS PPAR MODULATORS
- 专利标题（中）： 吲哚衍生物PPAR调节因子
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申请号： EP03800390.1申请日： 2003-12-31
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公开(公告)号： EP1581491A1公开(公告)日： 2005-10-05
- 发明人: CONNER, Scott, Eugene , KNOBELSDORF, James, Allen , MANTLO, Nathan, Bryan , MAYHUGH, Daniel, Ray , WANG, Xiaodong , ZHU, Guoxin , SCHKERYANTZ, Jeffrey, Michael , MICHELLYS, Pierre-Yves
- 申请人： ELI LILLY AND COMPANY , LIGAND PHARMACEUTICALS INCORPORATED
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY,LIGAND PHARMACEUTICALS INCORPORATED
- 当前专利权人： ELI LILLY AND COMPANY,LIGAND PHARMACEUTICALS INCORPORATED
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Bublak, Wolfgang
- 优先权： US438541P 20030106
- 国际公布： WO2004092131 20041028
- 主分类号： C07D209/08
- IPC分类号： C07D209/08 ; C07D209/42 ; C07D405/12 ; C07D409/12 ; C07D413/12 ; C07D413/14 ; C07D417/06 ; C07D417/12 ; C07D417/14 ; A61K31/404 ; A61K31/422 ; A61K31/427 ; A61K31/4402 ; A61K31/4409 ; A61K31/5377 ; A61P3/10 ; A61P29/00
摘要：
The present invention is directed to a method of treatment by modulating a peroxisome proliferator activated receptor by employing a compound of Structural Formula (I). The variables in (I) are defined herein. Also included are compounds, methods of making compounds, and pharmaceutical compositions. The compounds of the present invention are believed to be effective in treating and preventing Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, atherosclerosis, and other disorders related to Syndrome X and cardiovascular diseases.
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