发明授权
EP1587814B1 INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED 1-(HYDROXY-ETHYLIDENE)-1,1-BISPHOSPHONIC ACIDS OF HIGH PURITY AND THE SALTS THEREOF
有权
GROSS技术程序用于合成的高纯度的2-取代的1-（羟基亚乙基）-1,1-二膦及其盐的
- 专利标题： INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED 1-(HYDROXY-ETHYLIDENE)-1,1-BISPHOSPHONIC ACIDS OF HIGH PURITY AND THE SALTS THEREOF
- 专利标题（中）： GROSS技术程序用于合成的高纯度的2-取代的1-（羟基亚乙基）-1,1-二膦及其盐的
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申请号： EP04705466.3申请日： 2004-01-27
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公开(公告)号： EP1587814B1公开(公告)日： 2009-01-14
- 发明人: NEU, József , FISCHER, János , FODOR, Tamás , TÖRLEY, József , GIZUR, Tibor , LÉVAI, Sándor , DEMETER, Àdám , PERÉNYI, Éva
- 申请人： Richter Gedeon Nyrt.
- 申请人地址： Gyömröi út 19-21 1103 Budapest HU
- 专利权人： Richter Gedeon Nyrt.
- 当前专利权人： Richter Gedeon Nyrt.
- 当前专利权人地址： Gyömröi út 19-21 1103 Budapest HU
- 代理机构： HOFFMANN EITLE
- 优先权： HU0300227 20030128
- 国际公布： WO2004067541 20040812
- 主分类号： C07F9/58
- IPC分类号： C07F9/58 ; C07F9/38
摘要：
Process for the synthesis of high purity 2-substituted-1-(hydroxy-ethylidene)-1,1-bisphosphonic acid of formula (I), the salts and hydrates thereof - wherein the meaning of R is 3'-pyridyl or 2'-amino-ethylidene group - from compounds of formula (II) - wherein the meaning of R is as described above - or salts and hydrates thereof with phosphorous acid in the presence of methanesulfonic acid using phosphorus pentoxide as reagent and in given case the obtained acid is converted into a salt with base.
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