发明公开
- 专利标题: PROCESS FOR PREPARATION OF PERINDOPRIL AND SALTS THEREOF
- 专利标题(中): 用于生产培哚普利
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申请号: EP03720846.9申请日: 2003-02-28
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公开(公告)号: EP1603558A1公开(公告)日: 2005-12-14
- 发明人: DATTA, Debashish,Lupin Limited (Research Park) , SINGH, Girij, Pal,Lupin Limited (Research Park) , GODBOLE, Himanshu, Madhav,Lupin Limited , SIYAN, Rajinder Singh,Lupin Limited
- 申请人: Lupin Limited
- 申请人地址: 159 C.S.T. Road, Kalina, Santacruz (East) Mumbai 400 098,Maharashtra IN
- 专利权人: Lupin Limited
- 当前专利权人: Lupin Limited
- 当前专利权人地址: 159 C.S.T. Road, Kalina, Santacruz (East) Mumbai 400 098,Maharashtra IN
- 代理机构: Harrison Goddard Foote
- 国际公布: WO2004075889 20040910
- 主分类号: A61K31/4045
- IPC分类号: A61K31/4045 ; C07D209/42 ; A61P9/12
摘要:
A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective. The process involves reaction of compound of formula (I), wherein X is chlorine or bromine with compound of formula (VII) wherein A signifies that the six-membered ring of the bicyclic system is either saturated or unsaturated, followed by catalytic hydrogenation to give the perindopril of formula (II).
公开/授权文献
- EP1603558B1 PROCESS FOR PREPARATION OF PERINDOPRIL AND SALTS THEREOF 公开/授权日:2008-05-21
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