公开(公告)号：EP1603558A1

公开(公告)日：2005-12-14

申请号：EP03720846.9

申请日：2003-02-28

申请人： Lupin Limited

发明人： DATTA, Debashish,Lupin Limited (Research Park) ,  SINGH, Girij, Pal,Lupin Limited (Research Park) ,  GODBOLE, Himanshu, Madhav,Lupin Limited ,  SIYAN, Rajinder Singh,Lupin Limited

IPC分类号： A61K31/4045 ,  C07D209/42 ,  A61P9/12

CPC分类号： C07D209/42 ,  C07C227/32 ,  C07C227/34 ,  C07C229/12

摘要： A process for preparation of perindopril of formula (II) and salts thereof which is simple, safe, convenient and cost-effective. The process involves reaction of compound of formula (I), wherein X is chlorine or bromine with compound of formula (VII) wherein A signifies that the six-membered ring of the bicyclic system is either saturated or unsaturated, followed by catalytic hydrogenation to give the perindopril of formula (II).