发明公开
- 专利标题： IMPROVED ALPHAVIRUS REPLICONS AND HELPER CONSTRUCTS
- 专利标题（中）： 改进的阿巴卡韦复制和助手CONSTRUCT
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申请号： EP04757890.1申请日： 2004-03-19
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公开(公告)号： EP1608762A2公开(公告)日： 2005-12-28
- 发明人: SMITH, Jonathan, F. , KAMRUD, Kurt , RAYNER, Jon, O.
- 申请人： Alphavax, Inc.
- 申请人地址： P.O. Box 110307, 2 Triangle Drive Research Triangle Park, NC 27709-0307 US
- 专利权人： Alphavax, Inc.
- 当前专利权人： Alphavax, Inc.
- 当前专利权人地址： P.O. Box 110307, 2 Triangle Drive Research Triangle Park, NC 27709-0307 US
- 代理机构： Wright, Robert Gordon McRae
- 优先权： US456196P 20030320
- 国际公布： WO2004085660 20041007
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; A61K35/76 ; C07K14/18
摘要：
The present invention provides a recombinant nucleic acid comprising: a first nucleic acid sequence encoding a 5' alphavirus replication recognition sequence; at least one second nucleic acid sequence encoding an alphavirus nonstructural protein; at least one alphavirus subgenomic promoter; at least one IRES element; at least one heterologous nucleic acid; and a third nucleic acid encoding a 3' alphavirus replication recognition sequence. Further provided are methods of making alphavirus particles comprising a recombinant nucleic acid of this invention and methods of using the compositions of this invention. Also provided is a recombinant helper nucleic acid comprising: a first nucleic acid sequence encoding a 5' alphavirus replication recognition sequence; an alphavirus subgenomic promoter; an IRES element; a second nucleic acid encoding an alphavirus structural protein; and a third nucleic acid encoding a 3' alphavirus replication recognition sequence.
公开/授权文献
- EP1608762B1 IMPROVED ALPHAVIRUS REPLICONS AND HELPER CONSTRUCTS 公开/授权日：2014-01-08
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