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公开(公告)号：EP1751289A1
公开(公告)日：2007-02-14
申请号：EP05751967.0
申请日：2005-05-18
申请人： Alphavax, Inc.
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , A61K2039/575 , C07K14/005 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , C12N2770/36123 , C12N2770/36134 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/203
摘要： The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.
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公开(公告)号：EP1608762B1
公开(公告)日：2014-01-08
申请号：EP04757890.1
申请日：2004-03-19
申请人： Alphavax, Inc.
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16222 , C12N2740/16234 , C12N2770/36143 , C12N2770/36161 , C12N2770/36162 , C12N2820/60 , C12N2840/203
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公开(公告)号：EP1751289B1
公开(公告)日：2009-01-14
申请号：EP05751967.0
申请日：2005-05-18
申请人： Alphavax, Inc.
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/5256 , A61K2039/5258 , A61K2039/575 , C07K14/005 , C12N7/00 , C12N2740/16222 , C12N2740/16234 , C12N2770/36123 , C12N2770/36134 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/203
摘要： The present disclosure provides TC-83 VEE-derived replicons, alphaviral replicon particles and immunogenic compositions containing TC-83 alphaviral replicon particles which direct the expression of at least one antigen when introduced into a suitable host cell. The TC-83 VEE-derived ARPs described herein are improved in that they are subject to a lower vector-specific immune response than prior art ARPs.
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公开(公告)号：EP1608762A2
公开(公告)日：2005-12-28
申请号：EP04757890.1
申请日：2004-03-19
申请人： Alphavax, Inc.
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C12N7/00 , C12N15/86 , C12N2740/16122 , C12N2740/16222 , C12N2740/16234 , C12N2770/36143 , C12N2770/36161 , C12N2770/36162 , C12N2820/60 , C12N2840/203
摘要： The present invention provides a recombinant nucleic acid comprising: a first nucleic acid sequence encoding a 5' alphavirus replication recognition sequence; at least one second nucleic acid sequence encoding an alphavirus nonstructural protein; at least one alphavirus subgenomic promoter; at least one IRES element; at least one heterologous nucleic acid; and a third nucleic acid encoding a 3' alphavirus replication recognition sequence. Further provided are methods of making alphavirus particles comprising a recombinant nucleic acid of this invention and methods of using the compositions of this invention. Also provided is a recombinant helper nucleic acid comprising: a first nucleic acid sequence encoding a 5' alphavirus replication recognition sequence; an alphavirus subgenomic promoter; an IRES element; a second nucleic acid encoding an alphavirus structural protein; and a third nucleic acid encoding a 3' alphavirus replication recognition sequence.
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