发明公开
EP1616003A1 WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME
审中-公开
水溶性硫酯和selenoesters化合物和用于制备和使用它们的方法
- 专利标题： WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHODS FOR MAKING AND USING THE SAME
- 专利标题（中）： 水溶性硫酯和selenoesters化合物和用于制备和使用它们的方法
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申请号： EP03808599.9申请日： 2003-12-30
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公开(公告)号： EP1616003A1公开(公告)日： 2006-01-18
- 发明人: MIRANDA, Leslie, Phillip , KENT, Stephen, B., H.
- 申请人： Gryphon Therapeutics, Inc.
- 申请人地址： 600 Gateway Boulevard South San Francisco, CA 94080-7014 US
- 专利权人： Gryphon Therapeutics, Inc.
- 当前专利权人： Gryphon Therapeutics, Inc.
- 当前专利权人地址： 600 Gateway Boulevard South San Francisco, CA 94080-7014 US
- 代理机构： Harrison Goddard Foote
- 优先权： US437285P 20021230
- 国际公布： WO2004061094 20040722
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12N9/14 ; C07K14/47 ; C07C329/04 ; C07C391/00
摘要：
Water-soluble thioester and selenoester compounds, their generators, as well as methods for making and using the same, are provided. The subject thioester and selenoester compounds are characterized by including an amino acid synthon having a C-terminal group bonded to a water-soluble polymer through a thioester or selenoester linkage. Solid phase resins and protocols for generating the subject compounds are also provided. The subject water soluble thioester and selenoester compounds and generators find use in a variety of different applications, including thioester or selenoester mediated chemical ligation reactions.
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