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发明公开
EP1619194A2 Triazaspiro[5.5]undecane derivatives and pharmaceutical composition comprising the same as active ingredient 审中-公开
Triazaspiro [5.5] undecanderivative und dieses als aktiven Bestandteil enthaltende pharmazeutische Zusammensetzung

Triazaspiro[5.5]undecane derivatives and pharmaceutical composition comprising the same as active ingredient
摘要：
Triazaspiro[5.5]undecane derivatives of the formula (I), quaternary ammonium salts thereof, N-oxides thereof, non-toxic salts thereof, or pharmaceutical compositions comprising them, as active ingredients (wherein R 1 is formula (II) or formula (III); R 2 is alkyl or alkynyl etc.; R 3 , R 4 is H, (substituted) alkyl etc., or R 3 and R 4 together to form formula (IV); R 5 is H or alkyl).


Therefore the compounds of the formula (I) regulate the effect of chemokine/chemokine receptor, they are used for prevention and treatment of various inflammatory diseases, asthma, atopic dermatitis, urticaria, allergic diseases, nephritis, nephropathy, hepatitis, arthritis or rheumatoid arthritis etc.
摘要（中）：

式（I）的三氮杂螺[5.5]十一烷衍生物，其季铵盐，其N-氧化物，其无毒盐或包含它们的药物组合物作为活性成分（其中R 1为式（II）或式 III）; R 2是烷基或炔基等; R 3，R 4是H，（取代的）烷基等，或R 3和R 4一起形成式（IV）; R 5是H或烷基）。 因此，式（I）化合物调节趋化因子/趋化因子受体的作用，它们用于预防和治疗各种炎性疾病，哮喘，特应性皮炎，荨麻疹，过敏性疾病，肾炎，肾病，肝炎，关节炎或类风湿性关节炎 等等

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