发明授权
EP1633352B1 POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN
有权
具有抗肿瘤活性的聚烯烃恶唑及其使用链霉菌制备它们的方法
- 专利标题： POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN
- 专利标题（中）： 具有抗肿瘤活性的聚烯烃恶唑及其使用链霉菌制备它们的方法
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申请号： EP04737813.8申请日： 2004-06-14
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公开(公告)号： EP1633352B1公开(公告)日： 2006-11-02
- 发明人: MCALPINE, James, B. , FARNET, Chris, M , ZAZOPOULOS, Emmanuel , ISMAIL, Nargis , BACHMANN, Brian, O.
- 申请人： Ecopia Biosciences Inc.
- 申请人地址： 7290 Frederick-Banting Saint-Laurent, QC H4S 2A1 CA
- 专利权人： Ecopia Biosciences Inc.
- 当前专利权人： Ecopia Biosciences Inc.
- 当前专利权人地址： 7290 Frederick-Banting Saint-Laurent, QC H4S 2A1 CA
- 代理机构： Vossius & Partner
- 优先权： US477931P 20030613
- 国际公布： WO2004110439 20041223
- 主分类号： A61K31/422
- IPC分类号： A61K31/422 ; C07D413/12 ; A61K31/421 ; C07D263/32 ; C12P17/16 ; C12R1/60 ; A61P35/00
摘要：
This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof. The pharmaceutical composition comprising a compound of the invention is useful as a cytotoxic agent and for inhibiting the growth of cancer cells.
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