-
1.发明公开POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN 有权POLYENOXAZOLE具有抗肿瘤效应AND METHOD FOR THE PRODUCTION BY链霉菌的菌株来
公开(公告)号：EP1633352A1
公开(公告)日：2006-03-15
申请号：EP04737813.8
申请日：2004-06-14
发明人： MCALPINE, James, B. , FARNET, Chris, M , ZAZOPOULOS, Emmanuel , ISMAIL, Nargis , BACHMANN, Brian, O.
IPC分类号： A61K31/422 , C07D413/12 , A61K31/421 , C07D263/32 , C12P17/16 , C12R1/60 , A61P35/00
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof. The pharmaceutical composition comprising a compound of the invention is useful as a cytotoxic agent and for inhibiting the growth of cancer cells.
-
公开(公告)号：EP1539962A1
公开(公告)日：2005-06-15
申请号：EP04761767.5
申请日：2004-09-10
IPC分类号： C12N15/52 , C12N15/63 , C12P17/06 , C12P17/16 , C07D309/10 , C07D493/04 , C12P1/04 , C12N1/20 , A61P31/04 , A61K31/35 , C12P21/02 , C12N15/31 , C12N9/00 , C07K14/195
CPC分类号： C07C279/14 , C07C2601/10 , C07D309/10 , C07H5/04 , C07H5/06 , C12N15/52 , C12P7/42 , C12P13/001 , C12P13/02 , C12P17/06 , C12P17/16 , C12P19/44 , C12R1/01 , Y10S435/821
摘要： Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. Formula (I) One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC™ 43491 or a mutant or variant such as the strain IDAC-220604-1. Another method for obtaining the compounds is post-biosynthesis chemical modification of the compounds obtained by cultivation. Novel polynucleotide sequences and encoded proteins for the biosynthesis of the polyene polyketides are also presented.
摘要翻译： 已经发现新型多烯聚酮化合物，其药学上可接受的盐，前药和衍生物具有抗生素活性。 获得化合物的一种方法是通过种植侧寄生菌ATCC 43491或突变体或变体例如菌株IDAC-220604-1。 获得化合物的另一种方法是通过培养获得的化合物的后生物合成化学修饰。 还提出了用于多烯聚酮化合物的生物合成的新型多核苷酸序列和编码的蛋白质。
-
3.发明授权POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN 有权具有抗肿瘤活性的聚烯烃恶唑及其使用链霉菌制备它们的方法
公开(公告)号：EP1633352B1
公开(公告)日：2006-11-02
申请号：EP04737813.8
申请日：2004-06-14
发明人： MCALPINE, James, B. , FARNET, Chris, M , ZAZOPOULOS, Emmanuel , ISMAIL, Nargis , BACHMANN, Brian, O.
IPC分类号： A61K31/422 , C07D413/12 , A61K31/421 , C07D263/32 , C12P17/16 , C12R1/60 , A61P35/00
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof. The pharmaceutical composition comprising a compound of the invention is useful as a cytotoxic agent and for inhibiting the growth of cancer cells.
摘要翻译： 本发明涉及式（I）的新型生物活性多烯恶唑类，它们的药学上可接受的盐和衍生物，以及获得它们的方法。 一种获得化合物的方法是通过培育产卵链霉菌NRRL 2940或其突变体或变体。 包含本发明化合物的药物组合物可用作细胞毒剂并用于抑制癌细胞的生长。
-
4.发明公开FARNESYL DIBENZODIAZEPINONES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS 有权法呢dibenzodiazepines，方法和用途AS药物
公开(公告)号：EP1585814A1
公开(公告)日：2005-10-19
申请号：EP04703733.8
申请日：2004-01-21
发明人： BACHMANN, Brian, O. , MCALPINE, James, B. , ZAZOPOULOS, Emmanuel , FARNET, Chris, M. , PIRAEE, Mahmood
IPC分类号： C12N9/02 , C12N9/12 , C12N9/88 , C12N9/10 , C12N9/14 , C12N9/90 , C07D243/38 , A61K31/5513 , C12N1/20 , C12R1/29 , C12P17/10 , C12P17/16 , C12N15/74 , C12N15/03 , C07K14/195
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： The invention relates to biologically active dibenzodiazepinone analogs represented by Formula I, to methods of producing them, to pharmaceutical compositions comprising them and to methods of treating neoplastic conditions.
-
5.发明公开POLYENE POLYKETIDES, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS A PHARMACEUTICAL 有权POLYENPOLYKETIDE，对于其方法及其用作药物
公开(公告)号：EP1585752A1
公开(公告)日：2005-10-19
申请号：EP04703730.4
申请日：2004-01-21
IPC分类号： C07H15/203 , C07H15/26 , C07H15/10 , C07C229/30 , C07C237/16 , C12P19/44 , A61K31/7032 , A61P31/00
CPC分类号： C07H15/203 , C07C215/24 , C07C225/14 , C07C235/28 , C07C237/16 , C07C279/22 , C07C305/14 , C07C2601/10 , C07C2601/14 , C07H15/10 , C07H15/18 , C07H15/26 , C12P7/42 , C12P11/00 , C12P13/001 , C12P13/02 , C12P19/44 , C12R1/465 , Y10S435/886
摘要： This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.
-
6.发明公开METHOD, SYSTEM AND KNOWLEDGE REPOSITORY FOR IDENTIFYING A SECONDARY METABOLITE FROM A MICROORGANISM 审中-公开方法，系统和WISSENSSPEICHER二次代谢产物OFA微生物的检测
公开(公告)号：EP1470241A2
公开(公告)日：2004-10-27
申请号：EP03731645.2
申请日：2003-01-24
发明人： FARNET, Chris, M. , MCALPINE, James, B. , BACHMANN, Brian, O. , ZAZOPOULOS, Emmanuel , STAFFA, Alfredo , ZHAO, Zhizi , WONG, Sai, Man , DESJARDINS, Nicolas
CPC分类号： C12Q1/025
摘要： The invention relates to a method and system for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.024 秒)
