发明公开
- 专利标题： ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF
- 专利标题（中）： 表皮生长因子受体及其应用的抗体缺失突变体
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申请号： EP04777034申请日： 2004-06-25
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公开(公告)号： EP1638606A4公开(公告)日： 2009-06-03
- 发明人: WEBER RICHARD , FENG XIAO , FOORD ORIT , GREEN LARRY , GUDAS JEAN , KEYT BRUCE , LIU YING , RATHANASWAMI PALANI , RAYA ROBERT , YANG XIAO DONG , CORVALAN JOSE , FOLTZ IAN , JIA XIAO-CHI , KANG JASPAL , KING CHADWICK T , KLAKAMP SCOTT L , SU QIAOJUAN JANE
- 申请人： ABGENIX INC
- 专利权人： ABGENIX INC
- 当前专利权人： ABGENIX INC
- 优先权： US48314503 2003-06-27; US52557003 2003-11-26; US56245304 2004-04-15
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K47/48 ; C07K16/22 ; C07K16/28 ; C07K17/00 ; C12N20060101 ; C12N5/06 ; G01N33/53
摘要：
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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