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1.发明公开ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 有权表皮生长因子受体及其应用的抗体缺失突变体
公开(公告)号：EP1638606A4
公开(公告)日：2009-06-03
申请号：EP04777034
申请日：2004-06-25
申请人： ABGENIX INC
发明人： WEBER RICHARD , FENG XIAO , FOORD ORIT , GREEN LARRY , GUDAS JEAN , KEYT BRUCE , LIU YING , RATHANASWAMI PALANI , RAYA ROBERT , YANG XIAO DONG , CORVALAN JOSE , FOLTZ IAN , JIA XIAO-CHI , KANG JASPAL , KING CHADWICK T , KLAKAMP SCOTT L , SU QIAOJUAN JANE
IPC分类号： A61K39/395 , A61K47/48 , C07K16/22 , C07K16/28 , C07K17/00 , C12N20060101 , C12N5/06 , G01N33/53
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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公开(公告)号：EP1572900A4
公开(公告)日：2007-01-03
申请号：EP03705674
申请日：2003-01-06
申请人： ABGENIX INC
发明人： CORVALAN JOSE R F , JIA XIAO-CHI , FENG XIAO , YANG XIAO-DONG , CHEN FRANCINE , GAZIT GADI , WEBER RICHARD , BEZABEH BINYAM
CPC分类号： C07K16/22 , C07K2317/21 , C07K2317/56
摘要： The present invention is related to antibodies directed to the antigen PDGFD and uses of such antibodies. In particular, in accordance with the present invention, there are provided fully human monoclonal antibodies directed to the antigen PDGFD. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions CDR's, specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
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3.发明公开ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF 有权抗EGF（表皮生长因子）受体 - 抗体展望及其用途的缺失突变体
公开(公告)号：EP1639092A4
公开(公告)日：2009-06-03
申请号：EP04777147
申请日：2004-06-25
申请人： ABGENIX INC
发明人： WEBER RICHARD , FENG XIAO , FOORD ORIT , GREEN LARRY , GUDAS JEAN , KEYT BRUCE , LIU YING , RATHANASWAMI PALANI , RAYA ROBERT , YANG XIAO DONG , CORVALAN JOSE , FOLTZ IAN , JIA XIAO-CHI , KANG JASPAL , KING CHADWICK T , KLAKAMP SCOTT L , SU QIAOJUAN JANE
IPC分类号： A61K39/395 , A61K47/48 , C07K16/22 , C07K16/28 , C07K17/00 , C12N20060101 , C12N5/06 , G01N33/53
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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