发明授权
EP1648923B1 SPATIALLY-DEFINED MACROCYCLES INCORPORATING PEPTIDE BOND SURROGATES
有权
国土DEFINED大环肽键SURROGATE CONTAIN
- 专利标题： SPATIALLY-DEFINED MACROCYCLES INCORPORATING PEPTIDE BOND SURROGATES
- 专利标题（中）： 国土DEFINED大环肽键SURROGATE CONTAIN
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申请号： EP04761607.3申请日： 2004-08-02
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公开(公告)号： EP1648923B1公开(公告)日： 2008-12-31
- 发明人: DESLONGCHAMPS, Pierre , DORY, Yves , OUELLET, Luc , VILLENEUVE, Gérald , RAMASESHAN, Mahesh , FORTIN, Daniel , PETERSON, Mark , HOVEYDA, Hamid , BEAUBIEN, Sylvie , MARSAULT, Eric
- 申请人： Tranzyme Pharma Inc.
- 申请人地址： 3ème étage, 3001 12ème avenue Nord Fleurimont, Québec J1H 5N4 CA
- 专利权人： Tranzyme Pharma Inc.
- 当前专利权人： Tranzyme Pharma Inc.
- 当前专利权人地址： 3ème étage, 3001 12ème avenue Nord Fleurimont, Québec J1H 5N4 CA
- 代理机构： Chapman, Paul Gilmour
- 优先权： US491249P 20030731; US491253P 20030731; US491250P 20030731
- 国际公布： WO2005012332 20050210
- 主分类号： C07K5/00
- IPC分类号： C07K5/00 ; C07K5/08 ; C07K1/04
摘要：
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
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