发明公开
EP1656126A1 PREPARING METHOD FOR CONTROLLED RELEASED TYPE TABLET TAMSULOSIN HCL AND THE TABLET THEREOF
有权
PROCESS坦洛新HCL平板电脑控释和产生TABLET
- 专利标题: PREPARING METHOD FOR CONTROLLED RELEASED TYPE TABLET TAMSULOSIN HCL AND THE TABLET THEREOF
- 专利标题(中): PROCESS坦洛新HCL平板电脑控释和产生TABLET
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申请号: EP04773926.3申请日: 2004-06-15
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公开(公告)号: EP1656126A1公开(公告)日: 2006-05-17
- 发明人: LEE, Byoung-Suk , LEE, Ah-Ram , PARK, Jong-Sik , KIM, Eun-Ju , GIL, Hyung-Joon
- 申请人: Kyungdong Pharm. Co., Ltd.
- 申请人地址: 535-3, Daeyang-ri, Yanggam-myun Whaseong-si, Kyunggi-do 445-931 KR
- 专利权人: Kyungdong Pharm. Co., Ltd.
- 当前专利权人: Kyungdong Pharm. Co., Ltd.
- 当前专利权人地址: 535-3, Daeyang-ri, Yanggam-myun Whaseong-si, Kyunggi-do 445-931 KR
- 代理机构: Catherine, Alain
- 优先权: KR2003055579 20030812; KR2004023668 20040407
- 国际公布: WO2005013960 20050217
- 主分类号: A61K31/18
- IPC分类号: A61K31/18 ; A61K31/137 ; A61K47/14
摘要:
The present invention relates to a simple and effective method for preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl sustained-release tablet produced thereby. The method comprises the steps of: dissolving tamsulosin HCl as an active ingredient in an organic solvent; dissolving the tamsulosin HCl solution in hydroxypropylmethylcellulose phthalate to prepare a binder solution; and kneading the binder solution with a hydroxypropylmethylcellulose phthalate/glyceryl dibehenate mixture as an excipient and allows tamsulosin HCI to be released at uniformly controlled amounts in a subtained-release manner in vivo by controlling drug release rate according to different pH environments in vivo, so that it shows improved bioavailability and minimized side effects.
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