发明公开
EP1656126A1 PREPARING METHOD FOR CONTROLLED RELEASED TYPE TABLET TAMSULOSIN HCL AND THE TABLET THEREOF 有权
PROCESS坦洛新HCL平板电脑控释和产生TABLET

PREPARING METHOD FOR CONTROLLED RELEASED TYPE TABLET TAMSULOSIN HCL AND THE TABLET THEREOF
摘要:
The present invention relates to a simple and effective method for preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl sustained-release tablet produced thereby. The method comprises the steps of: dissolving tamsulosin HCl as an active ingredient in an organic solvent; dissolving the tamsulosin HCl solution in hydroxypropylmethylcellulose phthalate to prepare a binder solution; and kneading the binder solution with a hydroxypropylmethylcellulose phthalate/glyceryl dibehenate mixture as an excipient and allows tamsulosin HCI to be released at uniformly controlled amounts in a subtained-release manner in vivo by controlling drug release rate according to different pH environments in vivo, so that it shows improved bioavailability and minimized side effects.
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