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1.发明公开PREPARING METHOD FOR CONTROLLED RELEASED TYPE TABLET TAMSULOSIN HCL AND THE TABLET THEREOF 有权PROCESS坦洛新HCL平板电脑控释和产生TABLET
公开(公告)号：EP1656126A1
公开(公告)日：2006-05-17
申请号：EP04773926.3
申请日：2004-06-15
发明人： LEE, Byoung-Suk , LEE, Ah-Ram , PARK, Jong-Sik , KIM, Eun-Ju , GIL, Hyung-Joon
IPC分类号： A61K31/18 , A61K31/137 , A61K47/14
CPC分类号： A61K9/2018 , A61K9/2013 , A61K9/2054 , A61K9/2095 , A61K31/137 , A61K31/18 , Y10S514/96 , Y10S514/961 , Y10S514/964
摘要： The present invention relates to a simple and effective method for preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl sustained-release tablet produced thereby. The method comprises the steps of: dissolving tamsulosin HCl as an active ingredient in an organic solvent; dissolving the tamsulosin HCl solution in hydroxypropylmethylcellulose phthalate to prepare a binder solution; and kneading the binder solution with a hydroxypropylmethylcellulose phthalate/glyceryl dibehenate mixture as an excipient and allows tamsulosin HCI to be released at uniformly controlled amounts in a subtained-release manner in vivo by controlling drug release rate according to different pH environments in vivo, so that it shows improved bioavailability and minimized side effects.
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2.发明授权PREPARING METHOD FOR CONTROLLED RELEASED TYPE TABLET COMPRISING TAMSULOSIN HCL AND THE TABLET PRODUCED THEREOF 有权PROCESS坦洛新HCL平板电脑控释和产生TABLET
公开(公告)号：EP1656126B1
公开(公告)日：2011-08-10
申请号：EP04773926.3
申请日：2004-06-15
发明人： LEE, Byoung-Suk , LEE, Ah-Ram , PARK, Jong-Sik , KIM, Eun-Ju , GIL, Hyung-Joon
IPC分类号： A61K31/18 , A61K31/137 , A61K47/14
CPC分类号： A61K9/2018 , A61K9/2013 , A61K9/2054 , A61K9/2095 , A61K31/137 , A61K31/18 , Y10S514/96 , Y10S514/961 , Y10S514/964
摘要： The present invention relates to a simple and effective method for preparing a tamsulosin HCl sustained-release tablet and a tamsulosin HCl sustained-release tablet produced thereby. The method comprises the steps of: dissolving tamsulosin HCl as an active ingredient in an organic solvent; dissolving the tamsulosin HCl solution in hydroxypropylmethylcellulose phthalate to prepare a binder solution; and kneading the binder solution with a hydroxypropylmethylcellulose phthalate/glyceryl dibehenate mixture as an excipient and allows tamsulosin HCI to be released at uniformly controlled amounts in a subtained-release manner in vivo by controlling drug release rate according to different pH environments in vivo, so that it shows improved bioavailability and minimized side effects.
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