发明公开
EP1657235A2 Phenethanolamine-derived haptens, immunogens and conjugates comprising them and antibodies recognising said immunogenes and conjugates
有权
衍生的半抗原，免疫原和结合物含有它们的苯乙醇胺，和抗体针对这种免疫原性结合物和
- 专利标题： Phenethanolamine-derived haptens, immunogens and conjugates comprising them and antibodies recognising said immunogenes and conjugates
- 专利标题（中）： 衍生的半抗原，免疫原和结合物含有它们的苯乙醇胺，和抗体针对这种免疫原性结合物和
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申请号： EP05077582.4申请日： 2005-11-10
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公开(公告)号： EP1657235A2公开(公告)日： 2006-05-17
- 发明人: McConnell, Robert Ivan , Fitzgerald, Stephen Peter , Benchikh, El Ouard , Lowry, Andrew Philip
- 申请人： Randox Laboratories Ltd.
- 申请人地址： Ardmore, Diamond Road, Crumlin, County Antrim BT29 4QY GB
- 专利权人： Randox Laboratories Ltd.
- 当前专利权人： Randox Laboratories Ltd.
- 当前专利权人地址： Ardmore, Diamond Road, Crumlin, County Antrim BT29 4QY GB
- 代理机构： O'Connell, Maura
- 优先权： EP04078100 20041110
- 主分类号： C07C215/60
- IPC分类号： C07C215/60 ; C07C213/02 ; C07C215/56 ; C07K16/00 ; G01N33/48 ; G01N33/53 ; G01N33/532
摘要：
The present invention relates to a method for preparing haptens of formulae I and II that are useful in the preparation of immunogens, antibodies and conjugates, for use in competitive immunoassays for the detection of ractopamine, isoxsuprine and ritodrine. The haptens are prepared by reacting a phenylethanolamine derivative of formula D with a phenylalkylcarbonyl derivative of formula E:
in which, in formula I, Z 1 is a crosslinker and Z 2 is H and, in formula II, Z 1 is H and Z 2 is a crosslinker.
in which, in formula I, Z 1 is a crosslinker and Z 2 is H and, in formula II, Z 1 is H and Z 2 is a crosslinker.
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