公开(公告)号：EP4212509B1

公开(公告)日：2024-11-27

申请号：EP21865739.3

申请日：2021-08-04

Inventor： ZHANG, Pingping ,  LIU, Ye ,  YU, Guokun ,  ZHAO, Qiangfeng

IPC: C07C201/12 ,  C07C205/22 ,  C07C303/30 ,  C07C309/73 ,  C07C303/28 ,  C07C213/02 ,  C07C215/78 ,  C07C231/12 ,  C07C237/04 ,  C07C269/06 ,  C07C271/22

公开(公告)号：EP4342879A1

公开(公告)日：2024-03-27

申请号：EP22196808.4

申请日：2022-09-21

Applicant: F.I.S.- Fabbrica Italiana Sintetici S.p.A.

Inventor： Defilippo, Christian ,  Motterle, Riccardo

IPC: C07C213/02 ,  C07C231/02 ,  C07C233/22 ,  C07C217/60

Abstract: The present invention is directed to a very efficient process for the preparation of Agomelatine wherein the intermediate 7-methoxynaphtalenacetonitrile is reduced by Lithium Aluminium hydride in presence of a Lewis acid.

公开(公告)号：EP4323339A1

公开(公告)日：2024-02-21

申请号：EP22715113.1

申请日：2022-03-30

Applicant: BASF SE

Inventor： HUBER, Tatjana ,  PASTRE, Joerg ,  MELDER, Johann-peter ,  KRUG, Thomas ,  SCHROEDER, Kristin

IPC: C07D207/06 ,  C07C209/16 ,  C07C213/02 ,  C07C211/07 ,  C07C217/08

公开(公告)号：EP4313934A1

公开(公告)日：2024-02-07

申请号：EP22716396.1

申请日：2022-03-21

Applicant: Bracco Imaging SPA

Inventor： LATTUADA, Luciano ,  GIOVENZANA, Giovanni Battista ,  CAVALLOTTI, Camilla ,  MENEGOTTO, Ivan

IPC: C07C213/02 ,  C07C231/02 ,  C07C231/12 ,  C07D263/24 ,  C07C215/10 ,  C07C237/30 ,  C07C237/46

公开(公告)号：EP4310070A1

公开(公告)日：2024-01-24

申请号：EP21930957.2

申请日：2021-03-31

Applicant: Chengdu Shibeikang Biomedical Technology Co., Ltd.

Inventor： MOU, Xia ,  DONG, Bo ,  ZHANG, Hai ,  ZENG, Yanqun ,  XU, Xia ,  JIANG, Jie

IPC: C07C211/52 ,  C07C215/44 ,  C07C249/02 ,  C07C251/24 ,  C07C209/52 ,  C07C213/02 ,  A61K31/137 ,  A61P11/00 ,  A61P11/10 ,  A61P11/14

Abstract: The present invention pertains to the field of pharmaceutical chemistry, and discloses the use of a trans-amantadine derivative having a structure represented by Formula I or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for preventing or/and treating respiratory diseases. The trans-amantadine derivative and salt thereof according to the present invention have better efficacy than ambroxol hydrochloride and amantadine hydrochloride derivative racemate (mixture of isomers). From a mouse acute lung injury test and an ammonia-induced cough model in mice, it is shown to have excellent effects in treating lung injury and cough, which are were statistically superior to those of ambroxol hydrochloride and amantadine hydrochloride derivative racemate. The trans-amantadine ammonia derivative and its hydrochloride salt of the present invention can significantly increase the amount of sputum excreted by rats compared with ambroxol hydrochloride, and can significantly increase the excretion of phenol red in mice, with effects better than those of ambroxol hydrochloride and amantadine hydrochloride derivative racemate.

公开(公告)号：EP3766891B1

公开(公告)日：2023-11-01

申请号：EP19764436.2

申请日：2019-03-28

Inventor： SHI, Jicheng ,  ZHOU, Fabin

IPC: C07F9/50 ,  C07F9/6553 ,  B01J31/24 ,  C07C1/32 ,  C07C15/14 ,  C07C209/10 ,  C07C213/02 ,  C07C217/84 ,  C07D209/86 ,  C07D295/033 ,  C07D317/50 ,  C07F15/00 ,  C07C211/54

公开(公告)号：EP3983372B1

公开(公告)日：2023-08-09

申请号：EP20729077.6

申请日：2020-06-02

Inventor： ERNST, Martin ,  HUBER, Tatjana ,  MELDER, Johann-Peter ,  JAEGLI, Stephanie ,  KRUG, Thomas

IPC: C07C209/26 ,  C07C213/02 ,  C07C215/08 ,  C07C211/10

公开(公告)号：EP3166923B1

公开(公告)日：2023-03-15

申请号：EP15818168.5

申请日：2015-07-10

Inventor： LIAO, Subo ,  MCCLURG, Joseph ,  TRAWICK, Bobby

IPC: C07C213/08 ,  C07C217/62 ,  C07C213/02 ,  C07C45/62 ,  C07C45/65 ,  C07C45/69

公开(公告)号：EP4116289A1

公开(公告)日：2023-01-11

申请号：EP20922355.1

申请日：2020-03-31

Applicant: Asymchem Laboratories (Tianjin) Co., Ltd.

Inventor： HONG, Hao ,  JAMES, Gage ,  XIAO, Yi ,  ZHANG, Na ,  LI, Xiang ,  JIANG, Xiangjun ,  LV, Shunxing

IPC: C07C319/20 ,  C07C323/25 ,  C07C211/29 ,  C07C231/12 ,  C07C233/78 ,  C07C213/02 ,  C07C217/26 ,  C07C211/15 ,  C07C211/35 ,  C07D209/34 ,  C07D307/33 ,  C07D235/14 ,  C07D213/38 ,  C12N9/10 ,  C12P13/00 ,  C12P17/12

Abstract: The present invention provides a method for synthesizing a fluorine-containing chiral amine compound. The method comprised: reacting an amino donor with a fluorine-containing dihydroxy ketal compound under a catalysis of a transaminase to generate the fluorine-containing chiral amine compound, wherein the transaminase is derived from a plurality of strains. The transaminase of the present application has substrate specificity on the fluorine-containing dihydroxy ketal compound, and may effectively catalyze this type of the substrate to be converted into the fluorine-containing chiral amine compound. In addition, the transaminase has catalytic activity on a plurality of the fluorine-containing dihydroxy ketal compounds, and is relatively high in reaction selectivity and activity. The method catalyzed by the bio-enzyme is not only short in route, but also high in product yield, and the production using the method reduces cost, organic solvents and three wastes.

公开(公告)号：EP4013739A1

公开(公告)日：2022-06-22

申请号：EP20756849.4

申请日：2020-08-12

Applicant: Wella Germany GmbH

Inventor： SPECKBACHER, Markus ,  OSAN, Armin ,  ABEL, Heike ,  SCHLOTZHAUER, Gerd

IPC: C07C213/02 ,  C07C50/04 ,  C07C217/76