发明公开
EP1658074A1 INHIBITORS OF 2-OXOGLUTARATE DIOXYGENASE AS GAMMA GLOBIN INDUCERS
有权
2-酮戊二酸化酶抑制剂作为INDUKTOR GAMMAGLOBINS
- 专利标题： INHIBITORS OF 2-OXOGLUTARATE DIOXYGENASE AS GAMMA GLOBIN INDUCERS
- 专利标题（中）： 2-酮戊二酸化酶抑制剂作为INDUKTOR GAMMAGLOBINS
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申请号： EP04779849.1申请日： 2004-07-30
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公开(公告)号： EP1658074A1公开(公告)日： 2006-05-24
- 发明人: KLAUS, Stephen, J. , RATCLIFFE, Peter, J.
- 申请人： FIBROGEN, INC. , ISIS INNOVATION LIMITED
- 申请人地址： 225 Gateway Boulevard South San Francisco, CA 94080 US
- 专利权人： FIBROGEN, INC.,ISIS INNOVATION LIMITED
- 当前专利权人： FIBROGEN, INC.,ISIS INNOVATION LIMITED
- 当前专利权人地址： 225 Gateway Boulevard South San Francisco, CA 94080 US
- 代理机构： Goodfellow, Hugh Robin
- 优先权： US492045P 20030801
- 国际公布： WO2005011696 20050210
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/17 ; A61K31/19 ; A61P7/00 ; A61P7/06 ; A61P33/06 ; A61P43/00
摘要：
The present invention provides methods for increasing endogenous globin expression in a subject, specifically gamma-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., beta thalassemia and sickle cell disease.
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