公开(公告)号：EP1658074A1

公开(公告)日：2006-05-24

申请号：EP04779849.1

申请日：2004-07-30

申请人： FIBROGEN, INC. ,  ISIS INNOVATION LIMITED

发明人： KLAUS, Stephen, J. ,  RATCLIFFE, Peter, J.

IPC分类号： A61K31/47 ,  A61K31/17 ,  A61K31/19 ,  A61P7/00 ,  A61P7/06 ,  A61P33/06 ,  A61P43/00

CPC分类号： A61K31/7072 ,  A61K31/17 ,  A61K31/19 ,  A61K31/47 ,  Y02A50/411

摘要： The present invention provides methods for increasing endogenous globin expression in a subject, specifically gamma-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., beta thalassemia and sickle cell disease.

公开(公告)号：EP1658074B1

公开(公告)日：2012-11-07

申请号：EP04779849.1

申请日：2004-07-30

申请人： Fibrogen, Inc. ,  ISIS INNOVATION LIMITED

发明人： KLAUS, Stephen, J. ,  RATCLIFFE, Peter, J.

IPC分类号： A61K31/47 ,  A61K31/17 ,  A61K31/19 ,  A61P7/00 ,  A61P7/06 ,  A61P33/06 ,  A61P43/00

CPC分类号： A61K31/7072 ,  A61K31/17 ,  A61K31/19 ,  A61K31/47 ,  Y02A50/411

摘要： The present invention provides methods for increasing endogenous globin expression in a subject, specifically gamma-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., beta thalassemia and sickle cell disease.

公开(公告)号：EP2341904A1

公开(公告)日：2011-07-13

申请号：EP09789222.8

申请日：2009-08-26

申请人： Fibrogen, Inc.

发明人： KLAUS, Stephen, J. ,  NEFF, Thomas, B. ,  WALKINSHAW, Gail ,  CHOW, Aisha

IPC分类号： A61K31/352 ,  A61K31/465 ,  A61K45/06 ,  A61P25/28

CPC分类号： A61K45/06 ,  A61K31/352 ,  A61K31/465 ,  A61K2300/00

摘要： The present invention relates to methods and compounds useful for treating multiple sclerosis.

公开(公告)号：EP1919463B9

公开(公告)日：2011-02-02

申请号：EP06784964.6

申请日：2006-06-15

申请人： FIBROGEN, INC.

发明人： SEELEY, Todd, A. ,  LIU, David, Y. ,  KLAUS, Stephen, J.

IPC分类号： A61K31/00 ,  A61K31/4745 ,  A61K31/63 ,  A61P35/00

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/19 ,  A61K31/195 ,  A61K31/63 ,  A61K38/16

摘要： The invention relates to methods and compounds for treating or preventing cancer. Methods for treating or preventing cancer, for inhibiting tumor growth, reducing tumor volume, inhibiting tumor progression, inhibiting metastasis, and improving survival are provided herein.

公开(公告)号：EP1633333B1

公开(公告)日：2014-08-20

申请号：EP04754383.0

申请日：2004-06-04

申请人： Fibrogen, Inc.

发明人： KLAUS, Stephen, J. ,  MOLINEAUX, Christopher, J. ,  NEFF, Thomas, B. ,  GUENZLER-PUKALL, Volkmar ,  LANSETMO PAROBOK, Ingrid ,  SEELEY, Todd, W. ,  STEPHENSON, Robert, C.

IPC分类号： A61K31/00 ,  A61K31/395 ,  A61K31/165 ,  A61P7/06

CPC分类号： C07D217/24 ,  A61K31/00 ,  A61K31/165 ,  A61K31/17 ,  A61K31/395 ,  A61K31/472 ,  C07C275/40

摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.

摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。

公开(公告)号：EP2231157A1

公开(公告)日：2010-09-29

申请号：EP08860723.9

申请日：2008-12-08

申请人： Fibrogen, Inc.

发明人： KLAUS, Stephen, J. ,  LANGSETMO PAROBOK, Ingrid ,  SIRENKO, Oksana

IPC分类号： A61K31/472 ,  A61P9/00 ,  A61P43/00

CPC分类号： A61K31/472

摘要： The present invention relates to methods and compounds useful for increasing endothelial progenitor cell levels in blood and bone marrow. Methods and compounds for increasing endothelial progenitor cell mobilization are also provided.

公开(公告)号：EP2035000A1

公开(公告)日：2009-03-18

申请号：EP07796204.1

申请日：2007-06-14

申请人： FIBROGEN, INC.

发明人： SEELEY, Todd, W. ,  LIU, David, Y. ,  KLAUS, Stephen, J.

IPC分类号： A61K31/47 ,  A61P7/06

CPC分类号： A61K31/47

摘要： The invention relates to methods and compounds for treating anemia of cancer. In particular, methods for treating anemia of cancer in a subject having cancer, and methods for increasing reticulocytes, increasing hemoglobin, increasing hematocrit, and increasing red blood cell count in subjects having anemia of cancer, wherein such subjects are refractory to treatment with recombinant human erythropoietin (EPO) are encompassed herein.

公开(公告)号：EP1578431A2

公开(公告)日：2005-09-28

申请号：EP03796688.4

申请日：2003-12-05

申请人： FIBROGEN, INC.

发明人： FOURNEY, Patrick, D. ,  GUENZLER-PUKALL, Volkmar ,  KLAUS, Stephen, J. ,  LIN, Al, Y. ,  NEFF, Thomas, B. ,  SEELEY, Todd, W.

IPC分类号： A61K31/70

CPC分类号： A61K31/70 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.

公开(公告)号：EP1742965B1

公开(公告)日：2012-10-24

申请号：EP05779251.7

申请日：2005-04-28

申请人： Fibrogen, Inc.

发明人： SPONG, Suzanne, M. ,  NEFF, Thomas, B. ,  KLAUS, Stephen, J.

IPC分类号： C07K14/475

CPC分类号： A61K39/395 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/22 ,  G01N33/57438 ,  G01N2333/475

公开(公告)号：EP1991269A1

公开(公告)日：2008-11-19

申请号：EP07750392.8

申请日：2007-02-08

申请人： FIBROGEN, INC.

发明人： KLAUS, Stephen, J. ,  LANGSETMO PAROBOK, Ingrid ,  JACOB, Christopher, T.

IPC分类号： A61K45/00 ,  A61P9/10

CPC分类号： A61K45/06 ,  A61K31/121 ,  A61K31/194 ,  A61K38/49 ,  A61K2300/00

摘要： The present invention relates to methods and agents useful for the treatment of stroke, including ischemic stroke and hemorrhagic stroke. In particular, methods and agents for treating stroke in a subject are provided, wherein the agent is administered prior to diagnosis of the stroke as an ischemic stroke or a hemorrhagic stroke.

摘要翻译： 本发明涉及可用于治疗中风的方法和药剂，包括缺血性卒中和出血性中风。 特别地，提供了用于治疗受试者中风的方法和药剂，其中所述药物在诊断为中风之前作为缺血性中风或出血性中风进行施用。