发明公开
EP1661989A4 PROCESS FOR PREPARING RECOMBINANT CELL HAVING HIGH FIBRINOGEN PRODUCTION CAPABILITY AND CELL HAVING HIGH PRODUCTION CAPABILITY
有权
方法生产具有高FIBRINOGENPRODUKTIONSVERMÖGEN和生产能力高的重组细胞CELL
- 专利标题： PROCESS FOR PREPARING RECOMBINANT CELL HAVING HIGH FIBRINOGEN PRODUCTION CAPABILITY AND CELL HAVING HIGH PRODUCTION CAPABILITY
- 专利标题（中）： 方法生产具有高FIBRINOGENPRODUKTIONSVERMÖGEN和生产能力高的重组细胞CELL
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申请号： EP04770968申请日： 2004-07-28
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公开(公告)号： EP1661989A4公开(公告)日： 2009-05-20
- 发明人: MATSUYAMA REIKO , MAEDA HIROAKI
- 申请人： CHEMO SERO THERAPEUT RES INST
- 专利权人： CHEMO SERO THERAPEUT RES INST
- 当前专利权人： CHEMO SERO THERAPEUT RES INST
- 优先权： JP2003282033 2003-07-29; JP2004096215 2004-03-29
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; C07K14/75 ; C12N5/00
摘要：
Recombinant cells having high fibrinogen production capability are prepared by, in the incorporation of genes coding for three types of proteins constituting fibrinogen, namely, alpha-chain (or variant of alpha-chain), beta-chain and gamma-chain (or variant of gamma-chain) in animal cells, causing the gene composition ratio to be such that the amount of gamma-chain (and/or variant of gamma-chain) gene is equal to or more but not exceeding 1000 times the amount of alpha-chain (and/or variant of alpha-chain) gene and beta-chain gene and further by employing baculovirus P35 gene.
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