发明公开
EP1663202A1 SUBSTITUTED INDOLES AS INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP)
审中-公开
SUBSTITUTIERTE吲哚如聚（ADP-核糖）聚合酶的抑制剂（PARP）
- 专利标题： SUBSTITUTED INDOLES AS INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP)
- 专利标题（中）： SUBSTITUTIERTE吲哚如聚（ADP-核糖）聚合酶的抑制剂（PARP）
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申请号： EP04782937.9申请日： 2004-09-01
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公开(公告)号： EP1663202A1公开(公告)日： 2006-06-07
- 发明人: JIANG, John, Z. , KOEHL, Jack, R. , MEHDI, Shujaath , MOORCROFT, Neil , MUSICK, Kwon, Yon , WEINTRAUB, Philip, M. , EASTWOOD, Paul, R.
- 申请人： Aventis Pharmaceuticals, Inc.
- 申请人地址： 300 Somerset Corporate Boulevard Bridgewater, New Jersey 08807-2854 US
- 专利权人： Aventis Pharmaceuticals, Inc.
- 当前专利权人： Aventis Pharmaceuticals, Inc.
- 当前专利权人地址： 300 Somerset Corporate Boulevard Bridgewater, New Jersey 08807-2854 US
- 代理机构： Morel-Pécheux, Muriel
- 优先权： US500039P 20030904
- 国际公布： WO2005023246 20050317
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; A61P9/10 ; A61K31/541 ; A61K31/55 ; A61K31/496 ; A61K31/454 ; C07D209/40 ; C07D401/12 ; C07D409/04 ; C07D401/04 ; C07D471/04 ; C07D405/12 ; C07D403/04 ; C07D401/10 ; C07D403/10
摘要：
The present invention relates to a series of substituted indole derivatives of the formula I as described herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5’-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
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