发明公开
EP1663205A1 USE OF 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY
审中-公开
使用4,5-二氢-1H-吡唑衍生物的CB1拮抗剂活性
- 专利标题： USE OF 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY
- 专利标题（中）： 使用4,5-二氢-1H-吡唑衍生物的CB1拮抗剂活性
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申请号： EP04766644.1申请日： 2004-08-31
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公开(公告)号： EP1663205A1公开(公告)日： 2006-06-07
- 发明人: ANTEL, Jochen , KRAUSE, Günter , LANGE, Josephus, Hubertus, Maria , KRUSE, Cornelis, Gerrit , GREGORY, Peter-Colin , DEN BESTEN, Cathaline
- 申请人： Solvay Pharmaceuticals GmbH
- 申请人地址： Hans-Böckler-Allee 20 30173 Hannover DE
- 专利权人： Solvay Pharmaceuticals GmbH
- 当前专利权人： Solvay Pharmaceuticals GmbH
- 当前专利权人地址： Hans-Böckler-Allee 20 30173 Hannover DE
- 代理机构： Gosmann, Martin
- 优先权： EP03019939 20030902
- 国际公布： WO2005020988 20050310
- 主分类号： A61K31/415
- IPC分类号： A61K31/415 ; A61K31/4155 ; A61K31/4439 ; A61P3/04 ; A61P25/00
摘要：
The present invention relates to a novel medical use of 4,5-dihydro-1H-pyrazole compounds which are potent antagonists of the cannabis CB1-receptor. Said compounds are particularly suitable in the manufacture of medicaments for the treatment and/or prophylaxis of CB1 receptor related diseases in juvenile patients and/or for the treatment and/or prophylaxis of drug induced obesity in juvenile as well as in adolescent patients. The compounds have the general formula (1), wherein the group Bb represents sulfonyl or carbonyl, and the substituents R, R1, R2and R3, and the group Aa are defined as shown in the description.
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