公开(公告)号：EP4493189A1

公开(公告)日：2025-01-22

申请号：EP23720711.3

申请日：2023-03-13

Applicant: Laekna Limited

Inventor： LU, Chris ,  YUE, Yong ,  MA, Wenyue ,  LIU, Juan ,  CHEN, Yan

IPC: A61K31/4155 ,  C07K16/30 ,  A61P35/00

公开(公告)号：EP4480477A1

公开(公告)日：2024-12-25

申请号：EP23756633.6

申请日：2023-02-15

Applicant: Kanaph Therapeutics Inc. ,  Korea Research Institute of Chemical Technology

Inventor： HAN, Soo Bong ,  YUN, Chang Soo ,  LEE, Hyuk ,  KIM, Hyun Jin ,  LEE, Joo Youn ,  SEONG, Si Kwang ,  YOON, Taeyoung ,  LEE, Youngrae

IPC: A61K31/381 ,  A61K31/4155 ,  A61K31/397 ,  A61K31/4535 ,  A61K31/496 ,  A61K31/407 ,  A61K31/506 ,  A61K31/4439 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention provides a pharmaceutical composition for treating cancer, comprising, as active ingredients, an anticancer agent and a novel compound having an inhibitory activity with respect to prostaglandin E2 receptors. The novel compound of the present invention inhibits the activity of prostaglandin E2 receptors and suppresses the growth of tumors in colorectal cancer and lung cancer tumor models. In addition, it has been identified that coadministration with another anticancer agent of a chemotherapeutic anticancer agent and/or an immune checkpoint inhibitor exhibits synergistic effects with respect to anticancer activity. Therefore, the pharmaceutical composition for treating cancer, comprising the novel compound and the anticancer agent as active ingredients, can be effectively used in the prevention and treatment of cancer.

公开(公告)号：EP4475847A1

公开(公告)日：2024-12-18

申请号：EP23704956.4

申请日：2023-02-10

Applicant: Genome Research Limited ,  Stichting Het Nederlands Kanker Instituut- Antoni van Leeuwenhoek Ziekenhuis

Inventor： COKER, Elizabeth ,  EMERY, Amy ,  GARNETT, Mathew ,  JAAKS, Patricia ,  LIGHTFOOT, Howard ,  SANTOS, Jose Dianes ,  VIS, Daniel ,  WESSELS, Lodewyk ,  ZERBINO, Daniel

IPC: A61K31/4375 ,  A61K31/4985 ,  A61K45/06 ,  A61P35/00 ,  A61K31/4155 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/675 ,  A61K39/00 ,  A61K39/395

公开(公告)号：EP4424328A3

公开(公告)日：2024-12-04

申请号：EP24174854.0

申请日：2019-03-29

Applicant: Incyte Corporation

Inventor： HOWELL, Michael D. ,  SMITH, Paul

IPC: A61K31/4155 ,  A61K31/519 ,  A61K31/437 ,  A61P17/10 ,  A61K45/06 ,  A61K31/573

Abstract: The present application provides methods of treating hidradenitis suppurativa in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound which inhibits JAK1 and/or JAK2, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2948144B1

公开(公告)日：2024-12-04

申请号：EP14743956.6

申请日：2014-01-22

Inventor： HE, Biao ,  MANN, Michael ,  JABLONS, David M.

IPC: A61K31/415 ,  A61K45/06 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61K33/24 ,  C07D231/06 ,  C07D231/14 ,  C07D409/04

公开(公告)号：EP3846786B1

公开(公告)日：2024-11-13

申请号：EP19769675.0

申请日：2019-09-03

Inventor： KOLHE, Sachin, Pundlik ,  THAKUR, Supriya, Gautam

IPC: A61K9/20 ,  A61K31/365 ,  A61K31/7048 ,  A61K31/506 ,  A61K31/4155

公开(公告)号：EP3419612B1

公开(公告)日：2024-11-06

申请号：EP17757376.3

申请日：2017-02-24

Inventor： VERKMAN, Alan S. ,  HAGGIE, Peter M. ,  CIL, Onur

IPC: A61K31/437 ,  A61K31/4155 ,  A61K31/635 ,  A61K45/06 ,  A61P11/00 ,  A61P31/04 ,  A61P31/12 ,  C07D409/04 ,  C07D471/04

公开(公告)号：EP4346827A1

公开(公告)日：2024-04-10

申请号：EP22812121.6

申请日：2022-05-26

Applicant: Emory University

Inventor： GAVEGNANO, Christina ,  RIBEIRO, Susan Pereira

IPC: A61K31/4985 ,  A61K31/10 ,  A61K31/4155 ,  A61K31/519 ,  A61P35/00 ,  A61P35/02

公开(公告)号：EP4342894A1

公开(公告)日：2024-03-27

申请号：EP22833713.5

申请日：2022-07-01

Applicant: LG Chem, Ltd.

Inventor： LEE, Seok Ju ,  JEONG, Hui Rak ,  HAM, Jin Ok ,  SHIN, Doo Sup

IPC: C07D403/04 ,  A61K31/4155

Abstract: The present invention relates to a method for preparing a xanthine oxidase inhibitor and, more specifically, to a method for preparing a compound of chemical formula 2 by using ester hydrolysis and a recrystallization method.

公开(公告)号：EP4326256A1

公开(公告)日：2024-02-28

申请号：EP22792545.0

申请日：2022-04-22

Applicant: Kinnate Biopharma Inc.

Inventor： FRANOVIC, Aleksandra ,  MARTIN, Eric ,  MILLER, Nichol L. G. ,  MURPHY, Eric ,  WILLIAMS, Richard Thomas ,  KOBAYASHI, Ken

IPC: A61K31/397 ,  A61K31/4155 ,  A61K31/53