发明授权
- 专利标题： AMIDINES AND DERIVATIVES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
- 专利标题（中）： 脒及其衍生物和药物组合物含
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申请号： EP04787150.4申请日： 2004-09-16
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公开(公告)号： EP1663960B1公开(公告)日： 2011-08-24
- 发明人: ALLEGRETTI, Marcello , CESTA, Maria, Candida , NANO, Giuseppe , BERTINI, Riccardo , BIZZARRI, Cinzia , COLOTTA, Francesco
- 申请人： Dompe' S.P.A.
- 申请人地址： Località Campo di Pile snc 67100 L'Aquila IT
- 专利权人： Dompe' S.P.A.
- 当前专利权人： Dompe' S.P.A.
- 当前专利权人地址： Località Campo di Pile snc 67100 L'Aquila IT
- 代理机构： Perani, Aurelio
- 优先权： EP03103557 20030925
- 国际公布： WO2005028425 20050331
- 主分类号： C07C257/14
- IPC分类号： C07C257/14
摘要：
Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neutrophils induced by IL- 8. The compounds of the invention are used in the treatement of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
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