公开(公告)号：EP1660115B1

公开(公告)日：2011-06-22

申请号：EP04763431.6

申请日：2004-07-23

申请人： Dompe' S.P.A.

发明人： GIANNI, Alessandro, Massimo ,  CARLO-STELLA, Carmelo ,  COLOTTA, Francesco

IPC分类号： A61K38/18 ,  A61P7/00

CPC分类号： A61K38/1866 ,  A61K38/193 ,  A61K2300/00

摘要： Combined pharmaceutical preparation containing G-CSF and PIGF as the active substances, are useful in the mobilization of blood stem cells in a patient or subject in need thereof.

公开(公告)号：EP1590314A2

公开(公告)日：2005-11-02

申请号：EP04707926.4

申请日：2004-02-04

申请人： Dompe' S.P.A.

发明人： MORICONI, Alessio ,  ALLEGRETTI, Marcello ,  BERTINI, Riccardo ,  CESTA, Maria, Candida ,  BIZZARRI, Cinzia ,  COLOTTA, Francesco

IPC分类号： C07C63/04 ,  C07C65/32 ,  C07C59/205 ,  C07C311/29 ,  C07C311/02 ,  C07D207/32 ,  C07D295/12 ,  C07D209/42

CPC分类号： C07D207/337 ,  C07C57/30 ,  C07C57/58 ,  C07C311/09 ,  C07C311/21 ,  C07C311/51 ,  C07D209/26 ,  C07D209/42 ,  C07D295/13 ,  C07D471/04

摘要： Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.

公开(公告)号：EP1771468B1

公开(公告)日：2010-01-20

申请号：EP05764208.4

申请日：2005-07-21

申请人： Dompe' S.P.A.

发明人： GIANNI, Alessandro, M. ,  CARLO-STELLA, Carmelo ,  COLOTTA, Francesco

IPC分类号： C12N5/16 ,  C12N15/28 ,  C07K14/705

CPC分类号： C07K14/4747 ,  A61K2035/124

摘要： The invention refers to tumor-homing cells expressing the tumor necrosis factor-related apoptosis inducing ligand (TRIAL), particularly to CD34+ and NK cells transduced with adenoviral vectors coding for TRIAL. The cells of the invention are useful for the intravenous treatment of tumors, particularly of lymphoma.

公开(公告)号：EP1663960B1

公开(公告)日：2011-08-24

申请号：EP04787150.4

申请日：2004-09-16

申请人： Dompe' S.P.A.

发明人： ALLEGRETTI, Marcello ,  CESTA, Maria, Candida ,  NANO, Giuseppe ,  BERTINI, Riccardo ,  BIZZARRI, Cinzia ,  COLOTTA, Francesco

IPC分类号： C07C257/14

CPC分类号： C07C309/65 ,  C07C257/14 ,  C07D211/26 ,  C07D233/10 ,  C07D273/04 ,  C07D333/24

摘要： Amidines and derivatives thereof of formula (I) are described. The process for their preparation and pharmaceutical compositions thereof are also described. The amidines of the invention are useful in the inhibition of chemotaxis of neutrophils induced by IL- 8. The compounds of the invention are used in the treatement of psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.