发明公开
EP1675858A2 5-ARYL-PYRAZOLO [4,3-D] PYRIMIDINES, PYRIDINES, AND PYRAZINES AND RELATED COMPOUNDS
审中-公开
5-芳基 - 吡唑并[4,3-D]嘧啶，吡啶和吡嗪及相关化合物
- 专利标题： 5-ARYL-PYRAZOLO [4,3-D] PYRIMIDINES, PYRIDINES, AND PYRAZINES AND RELATED COMPOUNDS
- 专利标题（中）： 5-芳基 - 吡唑并[4,3-D]嘧啶，吡啶和吡嗪及相关化合物
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申请号： EP04788563.7申请日： 2004-09-03
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公开(公告)号： EP1675858A2公开(公告)日： 2006-07-05
- 发明人: HODGETTS, Kevin, J. , JOHN, Stanly , MOORCROFT, Neil , SHUTSKE, Greg , KAISER, Bernd , YAMAGUCHI, Yasuchika , GE, Ping , HORVATH, Raymond, F.
- 申请人： NEUROGEN CORPORATION , Aventis Pharmaceuticals, Inc.
- 申请人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 专利权人： NEUROGEN CORPORATION,Aventis Pharmaceuticals, Inc.
- 当前专利权人： NEUROGEN CORPORATION,Aventis Pharmaceuticals, Inc.
- 当前专利权人地址： 35 N.E. Industrial Road Branford, CT 06405 US
- 代理机构： Forstmeyer, Dietmar
- 优先权： US500033P 20030903
- 国际公布： WO2005028480 20050331
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; C07D471/04 ; C07D519/00 ; A61K31/519 ; A61K31/437 ; A61P25/18 ; A61P25/22
摘要：
5-aryl-Pyrazolo[4,3-d] pyrimidines, 6-aryl-Pyrazolo[3,4-d]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRIF receptor binding. Methods of using the compounds in receptor localization studies are given.
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