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1.发明公开HETEROARYL FUSED PYRIDINES, PYRAZINES AND PYRIMIDINES AS CRF1 RECEPTOR LIGANDS 审中-公开HETEROARYLKONDENSIERTE吡啶，吡嗪和嘧啶，其CRF1受体配体
公开(公告)号：EP1680424A2
公开(公告)日：2006-07-19
申请号：EP04788585.0
申请日：2004-09-03
发明人： GE, Ping , HORVATH, Raymond, F. , ZHANG, Lu, Yan , YAMAGUCHI, Yasuchika , KAISER, Bernd , ZHANG, Xuechun , ZHANG, Suoming , ZHAO, He , JOHN, Stanly , MOORCROFT, Neil , SHUTSKE, Greg
IPC分类号： C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： Substituted heteroaryl fused pyridine, pyrazine, and pyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
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2.发明公开5-ARYL-PYRAZOLO [4,3-D] PYRIMIDINES, PYRIDINES, AND PYRAZINES AND RELATED COMPOUNDS 审中-公开5-芳基 - 吡唑并[4,3-D]嘧啶，吡啶和吡嗪及相关化合物
公开(公告)号：EP1675858A2
公开(公告)日：2006-07-05
申请号：EP04788563.7
申请日：2004-09-03
发明人： HODGETTS, Kevin, J. , JOHN, Stanly , MOORCROFT, Neil , SHUTSKE, Greg , KAISER, Bernd , YAMAGUCHI, Yasuchika , GE, Ping , HORVATH, Raymond, F.
IPC分类号： C07D487/04 , C07D471/04 , C07D519/00 , A61K31/519 , A61K31/437 , A61P25/18 , A61P25/22
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： 5-aryl-Pyrazolo[4,3-d] pyrimidines, 6-aryl-Pyrazolo[3,4-d]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRIF receptor binding. Methods of using the compounds in receptor localization studies are given.
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3.发明公开5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS 审中-公开5-取代的2- arylpyrazines AS CRF受体的调节剂
公开(公告)号：EP1554258A1
公开(公告)日：2005-07-20
申请号：EP03793200.1
申请日：2003-08-20
发明人： YOON, Taeyoung , GE, Ping , DELOMBAERT, Stephane , HORVATH, Raymond , YAMAGUCHI, Yasuchika , DOLLER, Dario , LU, Jingqi , HODGETTS, Kevin, J. , JOHN, Stanly , KAISER, Bernd , ZHANG, Xeuchun , SHUTSKE, Greg , ZHANG, Cunyu , DARROW, Jim , MOORCROFT, Neil
IPC分类号： C07D241/20 , C07D241/18 , C07D241/26 , C07D401/04 , A61K31/497 , A61P25/22 , A61P25/24
CPC分类号： C07D241/12 , C07D241/18 , C07D241/20 , C07D241/26 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04
摘要： Novel 5-substituted-2-arylpyrazine compounds are provided. Such compounds can act as selective modulators of CRF receptors. The 5-substituted-2-arylpyrazine compounds provided herein are useful in the treatment of a number of CNS and peripheral disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds provided are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
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4.发明公开SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) 有权取代的吡啶酮的聚（ADP-核糖）聚合酶的抑制剂（PARP）
公开(公告)号：EP1732896A1
公开(公告)日：2006-12-20
申请号：EP05733556.4
申请日：2005-03-29
发明人： WEINTRAUB, Philip, M. , EASTWOOD, Paul, R. , MEHDI, Shujaath , STEFANY, David, W. , MUSICK, Kwon, Yon , MOORCROFT, Neil , LIM, Sungtaek , JIANG, John, Z. , RUTTEN, Hartmut , PEUKERT, Stefan , SCHWAHN, Uwe
IPC分类号： C07D213/62 , C07D217/24 , C07D401/04 , C07D413/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , A61K31/44 , A61P9/00 , A61P9/10 , A61P19/02 , A61P25/28 , A61P29/00
CPC分类号： C07D213/64 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14
摘要： The present invention discloses and claims a series of 2,3,5-substituted pyridone derivatives as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5'-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
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5.发明授权SUBSTITUTED PYRIDONES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) 有权取代的吡啶酮的聚（ADP-核糖）聚合酶的抑制剂（PARP）
公开(公告)号：EP1732896B1
公开(公告)日：2012-12-12
申请号：EP05733556.4
申请日：2005-03-29
发明人： WEINTRAUB, Philip, M. , EASTWOOD, Paul, R. , MEHDI, Shujaath , STEFANY, David, W. , MUSICK, Kwon, Yon , MOORCROFT, Neil , LIM, Sungtaek , JIANG, John, Z. , RUTTEN, Hartmut , PEUKERT, Stefan , SCHWAHN, Uwe
IPC分类号： C07D213/62 , C07D217/24 , C07D401/04 , C07D413/04 , C07D405/04 , C07D409/04 , C07D409/14 , C07D401/14 , C07D417/14 , A61K31/44 , A61P9/00 , A61P9/10 , A61P19/02 , A61P25/28 , A61P29/00
CPC分类号： C07D213/64 , C07D217/24 , C07D401/04 , C07D401/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/14
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6.发明公开SUBSTITUTED INDOLES AS INHIBITORS OF POLY (ADP-RIBOSE) POLYMERASE (PARP) 审中-公开SUBSTITUTIERTE吲哚如聚（ADP-核糖）聚合酶的抑制剂（PARP）
公开(公告)号：EP1663202A1
公开(公告)日：2006-06-07
申请号：EP04782937.9
申请日：2004-09-01
发明人： JIANG, John, Z. , KOEHL, Jack, R. , MEHDI, Shujaath , MOORCROFT, Neil , MUSICK, Kwon, Yon , WEINTRAUB, Philip, M. , EASTWOOD, Paul, R.
IPC分类号： A61K31/404 , A61P9/10 , A61K31/541 , A61K31/55 , A61K31/496 , A61K31/454 , C07D209/40 , C07D401/12 , C07D409/04 , C07D401/04 , C07D471/04 , C07D405/12 , C07D403/04 , C07D401/10 , C07D403/10
CPC分类号： C04B35/632 , A61K31/404 , A61K31/454 , A61K31/4745 , A61K31/496 , A61K31/503 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D209/40 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D471/04 , C07D487/08
摘要： The present invention relates to a series of substituted indole derivatives of the formula I as described herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5’-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.
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